Publications by authors named "G Labbadia"
Alkaline phosphatase (ALP) is abundantly represented in nature, being fundamental for a number of processes. In addition to its fundamental function in skeletal mineralization, its roles in the pathogenesis of other diseases are being explored. The measurement of total ALP activity in serum or in plasma is a useful biomarker in clinical practice.
View Article and Find Full Text PDFBackground: ANGPTL3 (angiopoietin-like 3) is a therapeutic target for reducing plasma levels of triglycerides and low-density lipoprotein cholesterol. A recent trial with vupanorsen, an antisense oligonucleotide targeting hepatic production of ANGPTL3, reported a dose-dependent increase in hepatic fat. It is unclear whether this adverse effect is due to an on-target effect of inhibiting hepatic ANGPTL3.
View Article and Find Full Text PDFHypersensitivity Myocarditis Following Deferasirox Administration.
Circ Cardiovasc Imaging
February 2022
Circulating dipeptidyl peptidase-4 is independently associated with the presence and severity of NAFLD/NASH in individuals with and without obesity and metabolic disease.
J Endocrinol Invest
May 2021
Article Synopsis
- The study investigates the relationship between dipeptidyl peptidase 4 (DPP4) levels and non-alcoholic fatty liver disease (NAFLD) in obese and non-obese individuals.
- Results show that NAFLD patients exhibit significantly higher circulating DPP4 activity compared to those without NAFLD, with a correlation between DPP4 levels and liver inflammation.
- The findings suggest that measuring circulating DPP4 could be an effective and economical way to assess NAFLD/NASH risk and monitor disease progression.
Introduction: In primary biliary cholangitis (PBC), macrophages are involved in liver inflammation and fibrosis. The macrophage activation markers, soluble (s)CD163 and mannose receptor (sMR) are associated with liver disease severity and prognosis in other chronic liver diseases. We aimed to investigate sCD163 and sMR in patients with PBC.
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