Publications by authors named "G L Woods"
Article Synopsis
- The study analyzes data from the Kids-DOTT trial to investigate the treatment and outcomes of children with cerebral sinovenous thrombosis (CSVT) compared to those with other types of venous thromboembolism (VTE).
- CSVT was found to be more common in neonates and young children, often linked to infections, while treatment involved varying durations of anticoagulation, with no significant difference in outcomes between 6 weeks and longer treatments.
- The findings suggest that 6 weeks of anticoagulant therapy is safe and effective for treating acute pediatric CSVT, but caution is advised in generalizing results due to the nature of subgroup analysis.
Introduction: Staphylococcus aureus bacteraemia (SAB) is the most common cause of sepsis, contributing to paediatric intensive care unit admission in Australia and New Zealand. While deep venous thrombosis (DVT) has been reported in children with invasive S. aureus infections, the actual frequency and possible effects of thrombosis on disease severity and outcome in paediatric SAB remain unknown.
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- Amphibians, like the cane toad, are key to understanding the evolution from water to land, but their brain activity has been challenging to study due to their unique physiology.
- A new method using flexible mesh electronics allows for extended brain activity recordings in both anesthetized and awake toads, marking a significant advancement in electrophysiology.
- This technique opens up opportunities to explore the neural mechanisms behind amphibian behaviors, paving the way for deeper insights into their complex activities.
Article Synopsis
- * Follow-up showed that most positive aPL were transient or low titer, while 10% met criteria for antiphospholipid syndrome (APS), which was linked to a significantly higher risk of recurrent VTE.
- * The research highlights the need for further studies on managing VTE in children, particularly for those diagnosed with APS, given their higher recurrence risk.
The major histocompatibility complex (MHC) molecules play an integral role in the adaptive immune response to transmissible cancers through tumour antigen presentation and recognition of allogeneic MHC molecules. The transmissible devil facial tumours 1 and 2 (DFT1 and DFT2) modulate MHC-I antigen presentation to evade host immune responses and facilitate transmission of tumours cells to new Tasmanian devil (Sarcophilus harrisii) hosts. To enhance T-cell-driven tumour immunogenicity for vaccination and immunotherapy, DFT1 and DFT2 cells were co-transfected with (i) NLRC5 for MHC-I expression or CIITA for MHC-I and MHC-II expression, and (ii) a co-stimulatory molecule, either CD80, CD86 or 41BBL.
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