Publications by authors named "G L Voronin"
Article Synopsis
- - CDD is a rare neurodevelopmental disorder linked to mutations in the CDKL5 gene, leading to symptoms like epilepsy, muscle weakness, and developmental delays.
- - Researchers created a gene therapy vector, AAV9.Syn.hCDKL5, to deliver the CDKL5 gene to the brain, using a specific promoter to enhance gene expression.
- - Studies in mice showed that injecting the vector directly into the cerebrospinal fluid improved distribution and resulted in biological activity, with successful functional improvements observed at higher doses.
Article Synopsis
- - Duchenne muscular dystrophy (DMD) is a severe genetic disorder leading to muscle loss and early mortality, with corticosteroids like deflazacort (FDA approved) and prednisone/prednisolone being standard treatments, while vamorolone is a new candidate under investigation.
- - In studies using a mouse model for DMD, vamorolone demonstrated unique pharmacokinetic properties, showing significant central nervous system (CNS) exposure compared to the other corticosteroids, which are strong p-glycoprotein substrates.
- - Although all three corticosteroids displayed effectiveness, they also caused side effects; especially, prednisolone and vamorolone were linked to changes in brain gene expression and depression-like behaviors, along
CHL1 is a close homolog of L1, a cell adhesion molecule that plays major roles in neural and tumor cell functions. We had found that young adult female mice deficient in CHL1 recovered better than their wild-type female littermates after thoracic Spinal Cord Injury (SCI). This observation was surprising, because CHL1 increases neurite outgrowth in vitro.
View Article and Find Full Text PDFThis paper presents clinical observations that can be regarded as degeneration of the basement membrane of the corneal epithelium. Difficulties in identifying such forms of corneal dystrophies, on the one hand, are associated with limitation and polymorphism of the clinical picture, and, on the other hand, with insufficient information content of the basic diagnostic methods (i.e.
View Article and Find Full Text PDFThe article reviews data on the impact of the position (orientation) of toric intraocular lenses on the functional outcomes of cataract phacoemulsification surgery, discusses the algorithm of astigmatism correction with intraocular lenses including preoperative determination of the size and position of main meridians, calculation of lens parameters, marking of corneal meridians, intraoperative positioning, as well as rotation and/or repositioning of the lens when necessary.
View Article and Find Full Text PDF