Machine learning-enhanced high-resolution exposure assessment of ultrafine particles.

Ultrafine particles (UFPs) under 100 nm pose significant health risks inadequately addressed by traditional mass-based metrics. The WHO emphasizes particle number concentration (PNC) for assessing UFP exposure, but large-scale evaluations remain scarce. In this study, we developed a stacking-based machine learning framework integrating data-driven and physical-chemical models for a national-scale UFP exposure assessment at 1 km spatial and 1-hour temporal resolutions, leveraging long-term standardized PNC measurements in Switzerland.

Multifunctional (CoFe)(S)-ion-microneedle patch: Synergistic antimicrobial, anti-inflammatory and cell proliferation for accelerating wound healing.

Preventing bacterial infection and accelerating wound closure are critical for wound healing. Herein, a novel multifunctional polyvinyl alcohol-polyvinylpyrrolidone (PVA-PVP) microneedle (MN) patch embedded with enzyme-like activity (CoFe)(S) (CFS) nanoparticles and metal ions (Co and Fe) was systematically synthesized for the management of bacteria-infected wounds. CFS regulated redox homeostasis and achieved bacterial eradication while concomitantly alleviating oxidative damage.

Dual-polarization O-band silicon photonics transmitter with an integrated tunable laser, Mach-Zehnder modulators, and SOAs.

Presented is an O-band silicon photonics dual-polarization coherent/IMDD modulator integrated with semiconductor optical amplifiers and tunable laser to enhance the short-reach link budget. The laser demonstrated output power >6 dBm and a <250 kHz linewidth over a 14 nm tuning range. Modulators paired with custom 64 Gbaud QPSK drivers exhibited improved analog link sensitivity compared to similar devices without integrated gain sections.

RNA binding protein ILF3 increases CEP55 mRNA stability to enhance malignant potential of breast cancer cells and suppress ferroptosis.

Background: Ferroptosis has emerged as a promising therapeutic target in cancer treatment. CEP55, a key regulator of cell mitosis, plays a significant role in the tumorigenesis of many malignancies. In this study, we elucidated the function of CEP55 in the ferroptosis of breast cancer (BC).