Publications by authors named "G L Scheffer"
Article Synopsis
- Colorectal surgery often leads to significant postoperative complications, mainly infections, potentially due to monocyte epigenetic changes and immune tolerance.
- A study involving 100 patients measured changes in damage-associated molecular patterns (DAMPs) and cytokine production, alongside exploratory analyses of proteins and DNA accessibility in monocytes.
- Results showed significant increases in plasma DAMPs, particularly HMGB1 and mitochondrial DNA post-surgery, while in vitro tests revealed that HSP70 and HMGB1 reduced the cytokine production capacity of immune cells.
Background: Concerns regarding residual neuromuscular block (RNMB) have persisted since the introduction of neuromuscular blocking agents, with reported incidences in the 21st century up to 50%. Advances in neuromuscular transmission (NMT) monitoring and the introduction of sugammadex have addressed this issue, but the impact of these developments remains unclear.
Methods: This prospective observational study evaluated RNMB in 500 surgical patients in a large Dutch teaching hospital with readily available quantitative NMT monitoring and reversal agents.
Article Synopsis
- The study looked at how safe it is for Physician Assistants to give sedation to kids during painful medical procedures like bone marrow tests.
- They checked if any kids had problems like low oxygen levels or needed extra help breathing during the process.
- The results showed that there were no serious issues and only a few minor problems, which suggests that it can be done safely by trained Physician Assistants.
Background: Increasing evidence supports a positive relationship between the intensity of early postoperative pain, and the risk of 30-day postoperative complications. Higher pain levels may hamper recovery and contribute to immunosuppression after surgery. This leaves patients at risk of postoperative complications.
View Article and Find Full Text PDFObjective: To compare the effectiveness of low intra-abdominal pressure (IAP) facilitated by deep neuromuscular block (NMB) to standard practice in improving the quality of recovery, preserving immune function, and enhancing parietal perfusion during robot-assisted radical prostatectomy (RARP).
Patients And Methods: In this blinded, randomised controlled trial, 96 patients were randomised to the experimental group with low IAP (8 mmHg) facilitated by deep NMB (post-tetanic count 1-2) or the control group with standard IAP (14 mmHg) and moderate NMB (train-of-four 1-2). Recovery was measured using the 40-item Quality of Recovery questionnaire and 36-item Short-Form Health survey.