Publications by authors named "G L Rigatelli"
Although anticoagulation remains the cornerstone treatment for patients with acute pulmonary embolism (PE), catheter-directed therapy (CDT) has generated great interest as an adjunctive option for those presenting with hemodynamic decompensation or high risk for deterioration and in whom systemic thrombolysis has failed or is contraindicated. However, randomized controlled data supporting the efficacy and safety of CDT in addition to antithrombotic therapy in patients with high-risk and intermediate- to high-risk PE compared with anticoagulation and systemic thrombolysis alone are lacking. This paucity of high-quality data hampers guideline recommendations regarding the optimal therapeutic approach in such patients with PE.
View Article and Find Full Text PDFCarina: A major determinant in the pathophysiology and treatment of coronary bifurcation lesions.
Catheter Cardiovasc Interv
December 2024
Article Synopsis
- Research over the past ten years has improved our understanding of coronary bifurcations, which are junctions in blood vessels that can be critical in heart conditions.
- The carina, or the central part of these bifurcations, influences important blood flow patterns and shear stress, which can affect the development of atherosclerosis.
- This review aims to summarize the current knowledge about the role of the carina in coronary bifurcations to help interventional cardiologists develop better treatment approaches.
Article Synopsis
- * The study included 226 patients with a mean age of 70.9 years, finding that DOAC treatment correlated with significantly lower all-cause and cardiovascular mortality compared to VKA treatment over a median follow-up of about 55 months.
- * VKA therapy was identified as an independent predictor of cardiovascular death, highlighting the advantages of using DOACs in patients with AF and coronary bifurcation lesions.