Biomarkers.

Background: TDP-43 (TAR DNA-binding protein 43) is one of the most frequently observed co-pathologies in Alzheimer's disease (AD). Recognizing the diversity of pathological features in individuals with AD, including the presence of TDP-43, may lead to more personalized and effective treatment approaches. We investigate ante-mortem cortical microstructural changes in MRI with subsequent autopsy confirmation of Alzheimer's disease neuropathological changes (ADNC) with and without TDP-43 comorbidity.

Alzheimer's Imaging Consortium.

Background: TDP-43 (TAR DNA-binding protein 43) is one of the most frequently observed co-pathologies in Alzheimer's disease (AD). Recognizing the diversity of pathological features in individuals with AD, including the presence of TDP-43, may lead to more personalized and effective treatment approaches. We investigate ante-mortem cortical microstructural changes in MRI with subsequent autopsy confirmation of Alzheimer's disease neuropathological changes (ADNC) with and without TDP-43 comorbidity.

Clinical utility of diffusion MRI-derived measures of cortical microstructure in a real-world memory clinic setting.

Objective: To investigate cortical microstructural measures from diffusion MRI as "neurodegeneration" markers that could improve prognostic accuracy in mild cognitive impairment (MCI).

Methods: The prognostic power of Amyloid/Tau/Neurodegeneration (ATN) biomarkers to predict progression from MCI to AD or non-AD dementia was investigated. Ninety patients underwent clinical evaluation (follow-up interval 32 ± 18 months), lumbar puncture, and MRI.

Macro and micro structural preservation of grey matter integrity after 24 weeks of rTMS in Alzheimer's disease patients: a pilot study.

Alzheimer's Disease (AD) is characterized by structural and functional dysfunction involving the Default Mode Network (DMN), for which the Precuneus (PC) is a key node. We proposed a randomized double-blind pilot study to determine neurobiological changes after 24 weeks of PC-rTMS in patients with mild-to-moderate AD. Sixteen patients were randomly assigned to SHAM or PC-rTMS, and received an intensive 2-weeks course with daily rTMS sessions, followed by a maintenance phase in which rTMS has been applied once a week.

In vivo cortical diffusion imaging relates to Alzheimer's disease neuropathology.

Background: There has been increasing interest in cortical microstructure as a complementary and earlier measure of neurodegeneration than macrostructural atrophy, but few papers have related cortical diffusion imaging to post-mortem neuropathology. This study aimed to characterise the associations between the main Alzheimer's disease (AD) neuropathological hallmarks and multiple cortical microstructural measures from in vivo diffusion MRI. Comorbidities and co-pathologies were also investigated.