Publications by authors named "G L Lanzino"
Cardiovascular disease remains a prominent cause of disability and premature death worldwide. Within this spectrum, carotid artery atherosclerosis is a complex and multifaceted condition, and a prominent precursor of acute ischaemic stroke and other cardiovascular events. The intricate interplay among inflammation, oxidative stress, endothelial dysfunction, lipid metabolism, and immune responses participates in the development of lesions, leading to luminal stenosis and potential plaque instability.
View Article and Find Full Text PDFPurpose: Familial cerebral cavernous malformation syndrome (FCCM) is characterized by multiple hemorrhagic lesions and is sometimes mistaken for cerebral amyloid angiopathy (CAA).
Methods: We compared clinical and radiologic characteristics in patients with definite (N = 32) and presumed FCCM (n = 76) to patients with definite (N = 29) and probable CAA (N = 21).
Results: Patients with CAA were older (78.
Article Synopsis
- Adult primary leptomeningeal gliomatosis (PLG) is a rare and aggressive disease that affects the meninges with glial tumor infiltration but no obvious brain mass, and it has not been thoroughly studied at the molecular level.
- In a study of six PLG patients, all showed leptomeningeal enhancement; most were diagnosed via biopsy revealing astrocytic gliomas with notable genetic mutations, including IDH-wildtype and TERT promoter alterations, which indicated similarities to adult-type glioblastoma.
- All patients unfortunately died from the disease, with a median survival of just 24 days after diagnosis, although one case with early intervention survived significantly longer, suggesting that early detection and treatment may
Introduction: Unlike spontaneous cervical artery dissection (CeAD), the incidence of CeAD after a major trauma is not well characterized. This population-based observational study investigates the epidemiology and natural history of traumatic cervical artery dissection (CeADs) using data from the Rochester Epidemiology Project (REP) in Olmsted County, USA.
Methods: The REP system database has a high likelihood of complete case ascertainment and comparable demographics (age, sex) to the US population.
Iatrogenic cervical artery dissections during endovascular interventions.
Interv Neuroradiol
December 2024
Background: Iatrogenic cervical artery dissection (CeAD) results from various procedures including interventional angiographic procedures and diagnostic angiography. Iatrogenic CeAD is rare, resulting in limited literature on management and outcomes. This observational cohort study investigates approaches and outcomes of iatrogenic CeAD after endovascular interventions.
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