Semaphorin 3E expression correlates inversely with Plexin D1 during tumor progression.

Plexin D1 (PLXND1) is broadly expressed on tumor vessels and tumor cells in a number of different human tumor types. Little is known, however, about the potential functional contribution of PLXND1 expression to tumor development. Expression of semaphorin 3E (Sema3E), one of the ligands for PLXND1, has previously been correlated with invasive behavior and metastasis, suggesting that the PLXND1-Sema3E interaction may play a role in tumor progression.

Micronodular transformation as a novel mechanism of VEGF-A-induced metastasis.

How and why tumors metastasize is still a matter of debate. The assumption is that mutations render tumor cells with a metastatic phenotype, enabling entrance in and transport through lymph or blood vessels. Distant outgrowth is thought to occur only in a suitable microenvironment (the seed and soil hypothesis).

[Nicotinic acid in the treatment of chronic circulatory failure in patients with ischemic heart disease].

Examined were 98 patients with chronic forms of ischemic heart disease, mainly atherosclerotic cardiosclerosis with different degrees of cardiac insufficiency. Two groups were distinguished. Patients of the first group received traditional treatment while patients of the second group received also nicotinic acid agents.

[The significance of the blood kinin system indices for the diagnosis of latent forms of rheumatism].

A study of the kinin and fibrinolytic systems of the blood in 280 rheumatic patients with isolated or prevailing stenosis revealed that latent forms of rheumatism were characterized by an increase of kininogenesis, reduction of kininase capacity of the blood and depression of fibrinolysis in the absence of acute-phase reactions which allows to use these data a supplementary informative test for the diagnosis of the latent course of rheumatism.