Publications by authors named "G L Holtzman"
Connectivity of the neuronal network for contextual fear memory is disrupted in a mouse model of third-trimester binge-like ethanol exposure.
Mitchell D Morningstar Katalina M Lopez Stefanie S Mayfield Roberto N Almeida-Mancero Joshua Marquez Gwen A Holtzman
Alcohol Clin Exp Res (Hoboken)
December 2024
Background: In rodents, third-trimester-equivalent alcohol exposure (TTAE) produces significant deficits in hippocampal-dependent memory processes such as contextual fear conditioning (CFC). The present study sought to characterize changes in both behavior and Fos neurons following CFC in ethanol (EtOH)-treated versus saline-treated mice using TRAP2:Ai14 mice that permanently label Fos neurons following a tamoxifen injection. We hypothesized that TTAE would produce long-lasting disruptions to the networks engaged following CFC with a particular emphasis on the limbic memory system.
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- Competency-based education (CBE) is being adopted in health professions, and this report focuses on creating a set of competencies for physical therapists as part of revamping their Doctor of Physical Therapy curriculum.
- A multi-step survey process was used to refine these competencies and achieve consensus among stakeholders, with an agreement threshold set at 85% for each item.
- The final outcome included 57 agreed-upon competencies organized into 8 domains, aiming to provide a coherent framework to improve physical therapist education and overall health care.
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- Early disparities in COVID-19 vaccination rates among racial groups have often been attributed to individual attitudes towards vaccines, but there may be deeper issues related to how vaccines were distributed.
- A study analyzed shipping data for over 385,000 doses in Pennsylvania's initial vaccine rollout and found that predominantly White neighborhoods received 81.4% more vaccine doses than Black neighborhoods.
- The results suggest that the distribution practices of pharmacy chains, rather than state or federal decisions, contributed significantly to this inequitable access, highlighting the need for regulation and monitoring of how public health resources are allocated.
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- Families in high-risk communities faced significant challenges during the COVID-19 pandemic, with a study conducted on parents from parochial schools in Chicago assessing their needs and children's well-being.
- The survey revealed a high response rate (69.1%) with most participants identifying as Hispanic/Latinx, highlighting some financial struggles, such as difficulties paying bills.
- Overall, parents reported their children were generally happy and hopeful, with notable decreases in feelings of irritability, loneliness, and isolation over time, indicating a positive shift in children's emotional well-being.
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- The PERSEUS mission is a proposed Heliophysics orbiter aimed at studying the unique magnetosphere and radiation environment of Uranus to better understand space physics.
- It will investigate Uranus's tilted magnetic field, its interactions with solar wind, and its intense radiation belts, providing insights relevant to both our knowledge of magnetospheric dynamics and potential exoplanetary systems.
- The mission concept has reached a good level of readiness and is designed to operate efficiently using advanced technology while incorporating a long hibernation phase during its 22-day orbit.