Publications by authors named "G L Gupte"
Article Synopsis
- - The text discusses the rising prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD), which has become the leading chronic liver disease globally among both children and adults, highlighting a lack of regional guidelines for its prevention and management in young populations.
- - A consensus meeting was held in Mumbai on April 20, 2024, where national and international experts collaborated to develop recommendations for the diagnostic evaluation and management of pediatric MASLD, given the condition's significant burden and epidemiology.
- - The recommendations suggest using the term MASLD instead of non-alcoholic fatty liver disease (NAFLD), noting that the disease is particularly common among overweight Indian children and adolescents, and is often asymptomatic or shows mild symptoms,
Article Synopsis
- Liver transplantation (LT) for children with glycogen storage disease type 1b can reduce infection-related hospital visits but does not improve neutropenia or the need for granulocyte colony-stimulating factor (G-CSF) post-transplant.
- In a study of eight children, most showed signs of graft rejection despite adequate immunosuppression, and while body mass index (BMI) significantly decreased, height remained unchanged after LT.
- The use of dapagliflozin helped stop G-CSF administration and led to lower gastrointestinal and infection-related issues, but did not enhance neutrophil counts.
Objective: To evaluate trends in etiology and outcomes of neonatal liver failure (NLF) over 30 years retrospectively at a single institution.
Study Design: Inclusion criteria for this retrospective cohort study were babies presenting at a chronological age of ≤28 days between 1991 and 2020 with prothrombin time ≥20 seconds and biochemical liver injury. Demographics, etiology, laboratory investigations, need for extrahepatic organ support, acute kidney injury, and intervention with liver transplant (LT) were recorded.
Article Synopsis
- * It is mostly caused by mutations in the C1 inhibitor gene, which is a protein that helps control a specific system in the body related to swelling.
- * A case is reported where an infant with this condition, after undergoing a liver transplant for a different issue, experienced normalization of C1 inhibitor levels, suggesting a potential cure for hereditary angioedema.
Article Synopsis
- Hepatic artery complications (HACs) after pediatric liver transplantation can lead to significant health issues, and this study aims to understand how common they are, how they are managed, and what outcomes arise from these complications.
- The research utilizes the international HEPATIC Registry, collecting data on pediatric patients under 18 who experienced HAC within the last 20 years, focusing on survival rates and treatment success.
- Ethical approval will be obtained from all participating sites, and findings will be shared at conferences and in academic journals, with the study registered on ClinicalTrials.gov (NCT05818644).