Publications by authors named "G L Galea"
Excessive deposition of fibrillar collagen in the interstitial extracellular matrix (ECM) of human lung tissue causes fibrosis, which can ultimately lead to organ failure. Despite our understanding of the molecular mechanisms underlying the disease, no cure for pulmonary fibrosis has yet been found. We screened a drug library and found that dextromethorphan (DXM), a cough expectorant, reduced the amount of excess fibrillar collagen deposited in the ECM in cultured primary human lung fibroblasts, a bleomycin mouse model, and a cultured human precision-cut lung slice model of lung fibrosis.
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- The processes of primary and secondary neurulation, which lead to spinal cord formation, are not fully understood in humans due to difficulties accessing embryos at the relevant stages (3-7 weeks post-conception).
- Analysis of 108 human embryos reveals that while primary neurulation is similar to that in mice, it has distinct differences; secondary neurulation begins later and forms a single lumen, unlike the multiple lumens seen in chicks.
- Key differences in neurulation timing between humans and mice were noted, such as the rate of somite formation and the termination of axial elongation associated with apoptosis in the embryonic tailbud; these findings can aid current research on neurulation using stem cell-derived organoids