Publications by authors named "G L D'Alessandro"
Background: Cystic echinococcosis (CE) is a significant public health issue, primarily affecting the liver. While several management strategies exist, there is a lack of predictive tools to guide surgical decisions for hepatic CE. This study aimed to develop predictive models to support surgical decision-making in hepatic CE, enhancing the precision of patient allocation to surgical or non-surgical management pathways.
View Article and Find Full Text PDFObjectives: HIV-1 infection continues to be a significant public health concern, notwithstanding the expanded utilization of antiretroviral treatment (ART), due to the emergence of drug resistance. The prevalence of transmitted drug resistance remains uncertain, particularly concerning integrase inhibitors. This study aimed to assess the extent of HIV resistance in both ART-naïve and experienced individuals living with HIV (PLHIV) at the University Hospital in Palermo, Italy.
View Article and Find Full Text PDFArticle Synopsis
- HAP1 is a human cell line that's good for studying gene changes and mutations due to its unique genetic makeup, but it's unusually sensitive to the cancer drug camptothecin.
- This sensitivity is linked to a problem with TDP1, an enzyme that helps fix certain DNA issues, specifically due to a mutation that disrupts its function.
- Researchers were able to use CRISPR technology to restore TDP1 in HAP1 cells, creating new cell lines that can be used for deeper studies on how DNA repairs itself in the presence of camptothecin.
The E3 ubiquitin ligase TRAIP associates with the replisome and helps this molecular machine deal with replication stress. Thus, TRAIP promotes DNA inter-strand crosslink repair by triggering the disassembly of CDC45-MCM2-7-GINS (CMG) helicases that have converged on these lesions. However, disassembly of single CMGs that have stalled temporarily would be deleterious, suggesting that TRAIP must be carefully regulated.
View Article and Find Full Text PDFArticle Synopsis
- Patients with severe obesity often experience psychiatric symptoms, which can influence their weight loss journey, especially after bariatric surgery.
- A study of 99 patients evaluated the link between negative emotional dysregulation (NED) and the effectiveness of weight loss following surgery, using various psychological assessment tools.
- Results showed that patients with NED (NED+) had a higher rate of inadequate weight loss one year post-surgery compared to those without NED (NED-), indicating a significant connection between emotional dysregulation and weight loss outcomes.