A Phase II Clinical Trial of Nivolumab and Temozolomide for Neuroendocrine Neoplasms.

Purpose: Treatment options are limited in patients with metastatic neuroendocrine neoplasms (NEN). We present the results for a phase II trial of combination nivolumab and temozolomide in patients with advanced NEN along with results of immune changes in peripheral blood.

Patients And Methods: NCT03728361 is a nonrandomized, phase II study of nivolumab and temozolomide in patients with NEN.

Links between sexuality, impulsivity, compulsivity, and addiction in a large sample of university students.

Objective: Non-heterosexual populations experience poorer mental health outcomes than their heterosexual counterparts. Few studies, however, have examined how mental health varies across the continuum of sexual orientation. Nor has any study examined possible links between sexual orientation and traits of impulsivity and compulsivity, which contribute to functional impairment across a broad spectrum of psychiatric disorders.

Prescription opioid medication misuse among university students.

Background And Objectives: Prescription opioid misuse is an established problem in the United States. Less information is known regarding the clinical and cognitive characteristics of prescription opioid misusers, specifically in a college age population. This study sought to characterize individuals who misuse prescription opioids and the differences between current, past and non-misusers.

Gambling and its clinical correlates in university students.

Objective: This study sought to examine the prevalence of gambling disorder (GD) in a university sample and its associated physical and mental health correlates.

Methods: A 156-item anonymous online survey was distributed via random email generation to a sample of 9449 university students. Current use of alcohol and drugs, psychological and physical status and academic performance were assessed, along with questionnaire-based measures of impulsivity and compulsivity.

The Young and the Stressed: Stress, Impulse Control, and Health in College Students.

High levels of stress are common among young adults, particularly those enrolled in college. These degrees of stress have shown numerous deleterious effects across both academic and health variables. Findings regarding the role of stress in the presentation of impulse control disorders, particular among college students, are limited.