Publications by authors named "G L Capretti"
Article Synopsis
- Long-term survivors of pancreatic cancer after surgery are rare, and a recent Italian survey aims to understand factors affecting their survival outcomes.
- The survey, endorsed by key oncological associations, gathered responses from surgeons to analyze demographics, clinical practices, and survival rates, revealing that long-term survival (LTS) is defined as being alive at 5 years post-surgery.
- Findings indicated improved survival rates for patients post-2013, especially in high-volume centers with multidisciplinary approaches, as well as those receiving neoadjuvant chemotherapy and having low-grade tumors.
Article Synopsis
- The study surveyed Italian pancreatic surgeons to assess their use of intraperitoneal prophylactic drains (IPDs) during distal pancreatectomy (DP) and to understand their regrets associated with drain decisions.
- Out of 106 respondents, 59.4% used at least one drain, but only a small percentage changed their strategies based on patient risk categories for postoperative pancreatic complications.
- Results showed that the median regret for not using an IPD when it would have been beneficial was high (80), while regret for using it unnecessarily was low (2.5), indicating a clear preference for cautious management in high-risk patients.
Introduction: Metabolic reprogramming is a hallmark feature of pancreatic ductal adenocarcinoma (PDAC). A pancreatic juice (PJ) metabolic signature has been reported to be prognostic of oncological outcome for PDAC. Integration of PJ profiling with transcriptomic and spatial characterization of the tumor microenvironment would help in identifying PDACs with peculiar vulnerabilities.
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