Publications by authors named "G L Allen"
Immune homeostasis requires a balance of inflammatory and suppressive activities. To design cells potentially useful for local immune suppression, we engineered conventional CD4 T cells with synthetic Notch (synNotch) receptors driving antigen-triggered production of anti-inflammatory payloads. Screening a diverse library of suppression programs, we observed the strongest suppression of cytotoxic T cell attack by the production of both anti-inflammatory factors (interleukin-10, transforming growth factor-β1, programmed death ligand 1) and sinks for proinflammatory cytokines (interleukin-2 receptor subunit CD25).
View Article and Find Full Text PDFArticle Synopsis
- - Robin sequence (RS) is characterized by a triad of micrognathia, glossoptosis, and airway obstruction, potentially leading to a cleft palate due to developmental issues.
- - RS can occur alone (isolated RS) or alongside other syndromes (syndromic RS), and diagnosis is primarily through clinical observation or imaging techniques like ultrasound and MRI.
- - Treatment aims to alleviate airway obstruction and glossoptosis through both conservative methods (like positioning and respiratory support) and surgical options (like tracheostomy and mandibular distraction), with ongoing research focused on genetics and improving detection and outcomes.
Cytosolic dependent translation supports mitochondrial RNA processing.
Proc Natl Acad Sci U S A
November 2024
Mitochondrial biogenesis relies on both the nuclear and mitochondrial genomes, and imbalance in their expression can lead to inborn errors of metabolism, inflammation, and aging. Here, we investigate N6AMT1, a nucleo-cytosolic methyltransferase that exhibits genetic codependency with mitochondria. We determine transcriptional and translational profiles of and report that it is required for the cytosolic translation of TRMT10C (MRPP1) and PRORP (MRPP3), two subunits of the mitochondrial RNAse P enzyme.
View Article and Find Full Text PDFIn the world of elite soccer, or football as we call it in the UK, a player who cannot play for any length of time costs the team money and team performance. The time to return to play (RTP) is crucial in any player's career, and the use of ultrasound-guided ultrasound injections has become important in the management of injury. In this article, I will explain the importance of good practice when performing these procedures and the use of steroids, sodium hyaluronic acid, platelet-rich plasma (PRP), and other therapies in achieving the goal of decreasing the time of RTP for the footballer.
View Article and Find Full Text PDFObjective: To quantify differences in levator veli palatini (LVP) muscle dimensions based on age, sex, and race and determine the typical range of asymmetry between the left and right sides of the LVP under age 2.
Design: Retrospective cohort study.
Setting: Children's tertiary care hospital.