Publications by authors named "G Kunkel"
Oxidant-free Au(I)/Au(III)-catalyzed cross-coupling has been recently enabled by the use of bidentate ,-ligands. To further develop these ,-ligands, computational studies were performed to understand their effects on the oxidative addition of aryl iodide electrophiles with Au(I). Using this mechanistic understanding, six new electron-rich ,-ligands were synthesized.
View Article and Find Full Text PDFObjective: Investigate the association between the MUC5B rs35705950 promoter variant and survival in RA-associated interstitial lung disease (RA-ILD).
Methods: We studied participants in the Veteran Affairs Rheumatoid Arthritis (VARA) registry with validated ILD diagnoses. Participants were followed until death or end of study period.
Article Synopsis
- - Organometallic oxidative addition complexes (OACs) are gaining attention as effective reagents for the selective modification of biomolecules by altering ligand and aryl properties to control reaction kinetics and regioselectivity.
- - Researchers explored the use of bidentate Au(III) OACs with bulky and electron-deficient aryl substrates to successfully achieve selective -arylation using computational and experimental methods.
- - The study successfully developed a protein-polymer OAC that performed rapid -arylation with designed ankyrin repeat proteins (DARPins) and various biologically relevant small molecules, paving the way for constructing complex biomolecular conjugates.
Introduction: Fluvoxamine is used in children and adolescents ('youths') for treating obsessive compulsive disorder (OCD) but also off-label for depressive and anxiety disorders. This study aimed to investigate the relationship between fluvoxamine dose and serum concentrations, independent correlates of fluvoxamine concentrations, and a preliminary therapeutic reference range (TRR) for youths with OCD and treatment response.
Methods: Multicenter naturalistic data of a therapeutic drug monitoring service, as well as prospective data of the 'TDM Vigil study' (EudraCT 2013-004881-33), were analyzed.
Article Synopsis
- Bioconjugation of polymers to proteins can enhance the stability and effectiveness of biologic systems, but the impact of different polymer structures is not fully understood.
- This study focuses on the first bioconjugation of a cyclic polymer, specifically poly(ethylene glycol), to a model protein (T4 lysozyme) to explore its unique properties.
- By comparing the cyclic polymer-protein conjugate with a linear version and using molecular dynamics simulations, the research aims to highlight the potential of cyclic polymers in improving therapeutic applications.