Publications by authors named "G Krupitza"
Article Synopsis
- - Epidemiological research suggests a link between electromagnetic fields (EMF) and certain cancers, with high frequency EMF (HF-EMF) relating to gliomas and low frequency EMF (LF-EMF) to childhood leukemia.
- - The study examined the effects of HF-EMF (1950 MHz) on DNA stability in astrocytoma cells and LF-EMF (50 Hz) in human lymphoma cells, exploring how these fields interact with chemically induced DNA damage.
- - Results showed a slight decrease in DNA damage in astrocytoma cells exposed to HF-EMF, but no significant changes in DNA integrity from either EMF type when compared with chemically induced damage, indicating that typical EMF
Article Synopsis
- Micronucleus (MN) assays using buccal cells are effective for assessing genetic damage in workers exposed to genotoxic metals, with most studies showing increased MN and nuclear anomalies among various occupations.
- A comprehensive review of 73 studies, mainly from South East Asia and South America, highlighted the need for better evaluation methods, as many studies lacked thorough assessments of genetic stability and cytotoxic effects.
- The data suggests that MN assays can provide valuable insights into chromosomal damage from metal exposure, complementing current chemical analysis and potentially enhancing workplace safety by reflecting biological impacts.
Article Synopsis
- Pleural mesothelioma (PM) is an aggressive type of cancer that grows in a unique tumor microenvironment (TME), but effective cell models for studying this environment are limited.
- Researchers developed new cell models using mesothelial cells and mesothelioma-associated fibroblasts (Meso-CAFs) from patients, which included the introduction of the hTERT gene to enhance cell growth capabilities.
- The study found that while these new hTERT-transduced models maintained key characteristics of primary cells, the conditioned media from both primary and transduced Meso-CAFs significantly stimulated PM cell growth, suggesting these models are effective for studying PM interactions in its TME.
A new flexible germacranolide (, lobatolide H) was isolated from the aerial parts of . The structure elucidation was performed by classical NMR experiments and DFT NMR calculations. Altogether, 80 theoretical level combinations with existing C NMR scaling factors were tested, and the best performing ones were applied on .
View Article and Find Full Text PDFArticle Synopsis
- Pleural mesothelioma (PM) is a highly aggressive cancer primarily characterized by the inactivation of tumor suppressor genes, with tumor microenvironment factors, such as cancer-associated fibroblasts (CAFs), influencing its progression.
- In this study, researchers isolated and characterized mesothelioma-associated fibroblasts (Meso-CAFs) from patients and examined their effects on PM cells, revealing that Meso-CAFs stimulate tumor cell growth and migration significantly.
- The study also found that targeted treatments, such as inhibitors for c-Met and PI3K, could reduce this stimulatory effect of Meso-CAFs on PM cells, indicating potential therapeutic strategies against the cancer's progression.