EU regulatory aspects of resistance risk assessment.

The EPPO Standard PP 1/213(1) on resistance risk analysis is the basis for risk assessment within the authorisation process in Germany. Data for resistance risk analysis have to be provided by the applicant and risk-mitigation strategies prepared if necessary. The extent of data requirements and the intensity of the evaluation process depend mainly on the type of target organism, crop, mode of action of the active substance and the resistance history of the organism in combination with products of similar mode of action as the one being applied for.

New reference values for routine blood samples and human neutrophilic lipocalin during third-trimester pregnancy.

Reference values are usually based on blood samples from healthy men or non-pregnant women. Blood samples from pregnant women may be compared with these reference values. Correct references for pregnancy can be extremely important for clinical decisions such as ablatio placentae, appendicitis, premature rupture of membranes and preeclampsia.

Rhodamine 123 fluorescence of immortal hybridoma cell lines as a function of glucose concentration.

The fluorescence of rhodamine 123 stained cells has been described to specifically reflect the activity of mitochondria. Changes in the intensity of fluorescence observed in stimulated lymphocytes were attributed to an increased glycolytic activity of cells due to increased growth rates. Previously reported changes in mitochondrial activity observed in batch cultures were likewise attributed to changed growth rates.

[The assessment of social relations in 6 to 12-year-old children in a child and adolescent population in psychiatric consultation].

Starting from Schmiedeck's "personal sphere model" we tried to develop a similar procedure for children (age range 6 to 12 years). It should enable us to analyze the social relationships of a patient from his/her point of view. We examined 85 children of child/adolescent-psychiatric population with the presented method.