[Malignant hyperthermia and neuroleptic malignant syndrome: report of 4 clinical cases].

Very numerous publication in the literature suggest the probable relationship between three clinical entities: peranesthesic malignant hyperthermia (PMH), exercitional malignant hyperthermia (EMH) and neuroleptic malignant syndrome (NMS). We briefly describe the clinical history and define, as subjects of research, the personal and familial histories of neuromuscular disease of 4 of our patients having presented with neuroleptic malignant syndrome, as recommended by the European group on malignant hyperthermia, the reference contracture test on neuromuscular fibers and anatomic and cytopathological investigations of neuromuscular fibers. We compare the results for our 4 patients having presented with neuroleptic malignant syndrome and their courses.

Long-term relationship between acute rhabdomyolysis and abnormal high-energy phosphate metabolism potentiated by ischemic exercise.

Relative concentrations of inorganic phosphate [Pi]r, creatine phosphate [CP]r, adenosine triphosphate [ATP]r, and intracellular pH (pHi) were determined by 31P-NMR spectroscopy in the flexores digitorum muscles. The measurements were performed at rest, during bouts of rhythmic exercises at different powers, including one with restricted blood supply, and during recovery. Normal subjects (N) and subjects with previous histories of exercise hyperthermia (EH) were compared.

Use of perfused isolated muscle, as studied by (31)P NMR, to investigate metabolism and post-mortem changes.

An experimental system was designed to study as independently as possible the effects of various in-vivo or post-mortem factors susceptible to influence muscle metabolism. This system was made up of an NMR probe, a physiological stimulator, a perfusion system and a force monitoring device. Rabbit muscles were isolated and perfused with bovine red cells, then put into the NMR probe to follow the evolution of pH and phosphorylated compounds.

Heterogeneity of metabolic response to muscular exercise in humans. New criteria of invariance defined by in vivo phosphorus-31 NMR spectroscopy.

31P NMR spectroscopy at 4.7 T has been used in vivo to follow metabolic changes associated with exercise and subsequent recovery in the forearm flexor digitorum superficialis muscle of 14 healthy volunteers. The muscle content in phosphomonoesters at rest provides an index of glycogenolytic activity.

Pi trapping in glycogenolytic pathway can explain transient Pi disappearance during recovery from muscular exercise. A 31P NMR study in the human.

31P NMR spectroscopy at 4.7 T has been used to follow changes in phosphorylated metabolites and pHi in the flexor digitorum superficialis muscle of 15 healthy volunteers subjected to a rest-exercise-recovery protocol. Phosphomonoesters (Pme) increased during exercise and exhibited a delayed recovery to resting level.