Nonreplacement therapy for hemophilia in low-income countries: experience from a prospective study in Ivory Coast.

Background: Hemophilia management has fundamentally evolved over the last decades with the development of ground-breaking therapies. Because of their mode of action and biochemical properties, these innovative therapies that are available in developed countries could be readily implemented among people from low-income countries who are either not or inadequately treated with clotting factor concentrates (CFCs).

Objectives: We aimed at evaluating the impact of prophylaxis with emicizumab, a bispecific monoclonal antibody mimicking the FVIII activity administered subcutaneously, among boys with severe hemophilia A (HA) from the Ivory Coast, where access to CFCs is limited to humanitarian aid.

Effect of Hevea brasiliensis seed meal or Euphorbia heterophylla seed supplemented diets on performance, physicochemical and sensory properties of eggs, and egg yolk fatty acid profile in guinea fowl (Numida meleagris).

A total of 144 French selected breed (Galor) female guinea fowl (GF) of 42 wk of age were enrolled for a feeding trial of 15, 30, and 45 D duration. The birds were randomly assigned to 18 cages, each containing 8 birds. A total of 3 isonitrogenous and isocaloric dietary treatments were trialed, each diet comprising 6 replications (cages), which meant a total of 48 birds per diet.

Diagnostic of guinea fowl (Numida meleagris) farming in Ivory Coast.

In order to promote farming of guinea fowl and to diversify the sources of income of Ivorian farmers, a survey was conducted in 2016 in 15 regions (197 farmers) out of a total of 31 regions in Ivory Coast. The aims were 1) to establish a better knowledge of guinea fowl farming; 2) to assess the level of technical knowledge of farmers; and 3) to establish a global typology of farmers based on their socio-economic profile, the goal of the farming (sale or consumption), and their level of technical knowledge. The sampling was realized according to a snowball type design (chain referral sampling method) a non-probabilistic method where farmers were selected not from a sampling frame but from the friendship network of existing farmers of the sample.

Effect of water activity on inactivation of Listeria monocytogenes and lactate dehydrogenase during high pressure processing.

The aim of this study was to investigate the effect of water activity (aw) on the inactivation of Listeria monocytogenes and lactate dehydrogenase (LDH) during high pressure processing (HPP). For microbial inactivation lyophilized cells of L. monocytogenes 19,115 were left dry or were suspended in 10 ml of 0.

Effect of high-pressure processing on activity and structure of alkaline phosphatase and lactate dehydrogenase in buffer and milk.

Changes in the activity and structure of alkaline phosphatase (ALP) and L-lactate dehydrogenase (LDH) were investigated after high pressure processing (HPP). HPP treatments (206-620 MPa for 6 and 12 min) were applied to ALP and LDH prepared in buffer, fat-free milk, and 2% fat milk. Enzyme activities were measured using enzymatic assays, and changes in structure were investigated using far-ultraviolet circular dichroism (CD) spectroscopy and dynamic light scattetering (DLS).