Publications by authors named "G Ko"
: Cellular and humoral immunity are key to the immune response against SARS-CoV-2, but the comparability and correlation across different assays remain underexplored. This study compares three T-cell and three antibody assays in two vaccine groups. : This prospective longitudinal cohort study involved 46 naïve healthcare workers: a total of 11 in the homologous mRNA-1273 group (three doses) and 35 in the heterologous ChAd group (two ChAd doses followed by a BNT booster).
View Article and Find Full Text PDFPeptide Lv is a small endogenous secretory peptide with ~40 amino acids and is highly conserved among certain several species. While it was first discovered that it augments L-type voltage-gated calcium channels (LTCCs) in neurons, thus it was named peptide "Lv", it can bind to vascular endothelial growth factor receptor 2 (VEGFR2) and has VEGF-like activities, including eliciting vasodilation and promoting angiogenesis. Not only does peptide Lv augment LTCCs in neurons and cardiomyocytes, but it also promotes the expression of intermediate-conductance K channels (K3.
View Article and Find Full Text PDFOptimal duration of medical therapy for patients with acute myocardial infarction.
Medicine (Baltimore)
November 2024
Article Synopsis
- The study analyzes the impact of optimal medical therapy, including Beta-blockers, RAS inhibitors, and statins, on patients who survived an acute myocardial infarction, revealing benefits in reducing cardiac mortality.
- During a follow-up of up to 2 years, RAS inhibitors and statins prescribed at 1-year showed a significant association with lower cardiac mortality, while Beta-blockers were only effective for the first year.
- Beyond 2 years, none of these medications demonstrated a significant impact on cardiac mortality, suggesting that their effectiveness diminishes over time.
Article Synopsis
- Heart degenerative diseases are hard to treat because the heart has a poor ability to regenerate lost cells called cardiomyocytes.
- Direct cellular reprogramming using small molecules offers a safer way to create functional cardiomyocytes without modifying genes, but the current methods are not very efficient and lead to immature cells.
- This study found that delivering mitochondria from high-energy organs can improve the maturity and functionality of chemically induced cardiomyocyte-like cells (CiCMs), which may enhance their potential use in regenerative medicine.
Red beetroots, rich in betanin, may act as prebiotics and impact gut microbiota. Because the human gut microbiota is unique to each person, the effectiveness of prebiotics varies with the enterotype. In this study, we hypothesized that the effects of red beetroot powder (RP) and betanin pigment (BP) would differ depending on the enterotype.
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