Clinician and Family Caregiver Perspectives on Deprescribing Chronic Disease Medications in Older Nursing Home Residents Near the End of Life.

Introduction: Nursing home (NH) residents with limited life expectancy (LLE) who are intensely treated for hyperlipidemia, hypertension, or diabetes may benefit from deprescribing.

Objective: This study sought to describe NH clinician and family caregiver perspectives on key influences on deprescribing decisions for chronic disease medications in NH residents near the end of life.

Methods: We recruited family caregivers of veterans who recently died in a Veterans Affairs (VA) NH, known as community living centers (CLCs), and CLC healthcare clinicians (physicians, nurse practitioners, physician assistants, pharmacists, registered nurses).

Smart process development: Application of machine-learning and integrated process modeling for inclusion body purification processes.

The development of a biopharmaceutical production process usually occurs sequentially, and tedious optimization of each individual unit operation is very time-consuming. Here, the conditions established as optimal for one-step serve as input for the following step. Yet, this strategy does not consider potential interactions between a priori distant process steps and therefore cannot guarantee for optimal overall process performance.

Improvement in Luminescence Intensity of β-NaYF: 18%Yb, 2%Er@β-NaYF Nanoparticles as a Result of Synthesis in the Presence of Stearic Acid.

The synthesis of upconverting nanoparticles (NPs) is crucial for their spectroscopic properties and further applications. Reducing the size of materials to nano-dimensions usually decreases emission intensity. Therefore, scientists around the world are trying to improve the methods of obtaining NPs to approach levels of emission intensity similar to their bulk counterparts.

Using Intervention Mapping to Develop a Novel Pain Self-Management Intervention for People with Cirrhosis.

Background: Chronic pain is common among patients with cirrhosis and is challenging to treat. While promising, pain self-management (PSM) interventions have not been tailored to this population's needs.

Aims: To design a PSM intervention for patients with cirrhosis.