Transcriptomic clustering of chronic lymphocytic leukemia: molecular subtypes based on Bruton's tyrosine kinase expression levels.

Historically, CLL prognostication relied on disease burden, reflected in clinical stage. Later, chromosome abnormalities and genomics suggested several CLL subtypes which were aligned with response to therapy. Gene expression profiling data identified pathways associated with CLL progression.

Promoting antihepatocellular carcinoma activity against human HepG2 cells via pyridine substituted palladium complexes: in vitro evaluation and QSAR studies.

Bis(4-(4-nitrobenzyl)pyridine)dichloropalladium(II), [PdClL], bis(2-amino-5-bromopyridine)dichloropalladium(II), [PdClL], bis(2,4-dimethylpyridine)dichloropalladium(II), [PdClL], bis(3,4-dimethylpyridine)dichloropalladium(II), [PdClL] were prepared. The spectroscopic techniques (FT-IR and H-NMR, C-NMR) were used to characterize the compounds. Theoretical calculations were used to validate the experimental results.

Development of a safety protocol for training and using SARS-CoV-2 detection dogs: A pilot study.

Medical detection dogs have potential to be used to screen asymptomatic patients in crowded areas at risk of epidemics such as the SARS-CoV-2 pandemic. However, the fact that SARS-CoV-2 detection dogs are in direct contact with infected people or materials raises important concerns due to the zoonotic potential of the virus. No study has yet recommended a safety protocol to ensure the health of SARS- CoV-2 detection dogs during training and working in public areas.

Is diagnostic performance of SARS-CoV-2 detection dogs reduced -due to virus variation- over the time?

Medical detection dogs have a high potential for use as alternative diagnostic tools not only for organic diseases, but also for infectious diseases. However, new variants emerging over time may affect the accuracy and sensitivity of diagnostic methods including medical detection dogs in case of viral pandemics. To the best of our knowledge, this is a pioneer study aimed to investigate diagnostic performances and generalization ability of SARS-CoV-2 detection dogs against the new variant after being trained with the original virus.

Effects of radiofrequency radiation on apoptotic and antiapoptotic factors in colorectal cancer cells.

In this study, it is aimed to investigate the effect of radiofrequency radiation (RFR) on apoptotic and antiapoptotic factors under different exposure conditions in human colonic adenocarcinoma cells (Caco-2). We analyzed the effects of 2.5 GHz continuous wave and 3 GPP modulated radiofrequency radiation exposure (15 min on, 15 min off) for 1 h and (1 h on, 1 h off) for 3 hours on Caco-2 cell lines.