[Clinical relevance of acetylator phenotyping in 196 urothelial tumor patients].

A total of 196 patients with urothelial tumours were phenotyped for N-acetyltransferase 2 by the molar ratio of two caffeine metabolites excreted in urine. The proportion of "slow" acetylators, who are genetically predisposed to urothelial tumours if they have been exposed to aromatic amines in the past, in the entire group was 55%, within the range in a normal population. Among 40 patients with assumed former occupational exposure to aromatic amines, 65% were "slow" acetylators.

Occupational history and genetic N-acetyltransferase polymorphism in urothelial cancer patients of Leverkusen, Germany.

Objectives: The study was designed to realize possible shifts in the ratio of slow to fast acetylators within a group of 196 urothelial cancer patients in an area with earlier benzidine production.

Methods: The subjects were interviewed for occupational and nonoccupational risk factors. The patients were phenotyped for N-acetyltransferase 2 (NAT2) by Grant's caffeine test.

[Urothelial diseases as an occupational disease].

The number of urothelial tumors of the lower urinary tract caused by occupational exposure is expected to markedly exceed the number of diseases which are actually compensated. The German compensation system for diseases is explained using the example of disease number 1301 which applies to bladder diseases due to aromatic amines. A standard procedure for the evaluation of the percentage of disability ("MdE") caused by tumors of the urinary bladder is presented.

[Revascularization of the penis in vascular-induced erectile dysfunction: clinical results of the Hauri surgical method].

Hauri's modification of the procedure for operative penile revascularization has been known since 1983; it is characterized by an anastomosis between the inferior epigastric artery and the dorsal artery of the penis with an arteriovenous shunt with the deep dorsal vein of the penis. Since 1986 this surgical technique has been applied in 18 patients with vascular erectile dysfunction. Their average age was 47 years, and the mean observation period was 8 months.

[Results of single-stage repair of distal hypospadias using the King modification].

From 1975 to 1986 34 patients undergoing repair of distal hypospadias between the age of 2 and 11 were explored. Standard method of the one-stage correction of distal hypospadias without or with moderate chordee was the operative technique according to the modification of King. After rolling the urethral groove into a tube the neourethra is covered with an asymmetrical part of dorsal hood.