Publications by authors named "G Kaysen"
Objectives: The importance of muscle wasting as a predictor of mortality in the hemodialysis population is not clear. Lack of association of muscle mass with survival in some studies could be related to reliance on single measures or to incorporation of excess extracellular water (ECW) into estimates of muscle mass. We examined changes in body composition over a 2-year period and the association of body composition with survival.
View Article and Find Full Text PDFIntroduction: The Frequent Hemodialysis Network (FHN) Daily and Nocturnal trials aimed to compare the effects of hemodialysis (HD) given 6 versus 3 times per week. More frequent in-center HD significantly reduced left-ventricular mass (LVM), with more pronounced effects in patients with low urine volumes. In this study, we aimed to explore another potential effect modifier: the predialysis serum sodium (SNa) and related proxies of plasma tonicity.
View Article and Find Full Text PDFArticle Synopsis
- Irisin, a hormone linked to muscle activity, was studied in hemodialysis patients to assess its levels and effects on health outcomes, particularly mortality.
- Findings indicated that lower muscle mass and higher inflammation (measured by IL-6) were related to higher irisin levels, suggesting that body composition and inflammatory status affect hormone concentration.
- Higher serum irisin levels at baseline and increased levels over a year correlated with an increased risk of death, pointing to a potential connection between irisin, inflammation, and mortality.
The National Kidney Foundation's Kidney Disease Outcomes Quality Initiative (KDOQI) has provided evidence-based guidelines for nutrition in kidney diseases since 1999. Since the publication of the first KDOQI nutrition guideline, there has been a great accumulation of new evidence regarding the management of nutritional aspects of kidney disease and sophistication in the guidelines process. The 2020 update to the KDOQI Clinical Practice Guideline for Nutrition in CKD was developed as a joint effort with the Academy of Nutrition and Dietetics (Academy).
View Article and Find Full Text PDFBackground: Frequent hemodialysis modifies serum phosphorus, blood pressure, and left ventricular mass (LVM). We ascertained whether frequent hemodialysis is associated with specific changes in biomarker profile among patients enrolled in the frequent hemodialysis network (FHN) trials.
Methods: This was a post hoc analysis of biomarkers among patients enrolled to the FHN trials.