Publications by authors named "G Karna"
Phenytoin is one of the most used antiepileptic drugs. Isoniazid, a first-line antitubercular drug, blocks the CYP2C19 enzyme, preventing phenytoin from being metabolised. Concomitant use of phenytoin and isoniazid predisposes to phenytoin toxicity.
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- Noncommunicable diseases, particularly cancer, are major contributors to global health issues, prompting this study to explore the prevalence of endocrine disorders like diabetes and thyroid dysfunction in advanced cancer patients receiving treatment.
- A total of 100 patients were enrolled over 15 months, with assessments made at the start and after 3 and 6 months of therapy, revealing that the prevalence of endocrine disorders rose from 10% to 18% during the study period, primarily affecting females.
- While no significant links were found between sociodemographic factors and endocrine status changes, smoking was identified as a risk factor for developing diabetes among these patients.
Timely diagnosis, comprehensive assessment, and a multidisciplinary treatment approach are essential for young patients with esophageal squamous cell carcinoma, even when conventional risk factors are absent. This report emphasizes the need for increased clinical awareness and improved patient outcomes in an evolving epidemiological landscape.
View Article and Find Full Text PDFBackground: Mandibular angle fracture are frequently associated with presence of third molar. This study aimed at assessing the role of third molar with angle fracture in relation to its positioning and the remaining bone between the apex of third molar and inferior border of mandible.
Methods: A retrospective study of all patients who reported for treatment of mandibular fracture between January 2019 to January 2021 were undertaken.
Introduction: COVID-19 vaccine-induced serious adverse reactions are rare. Hypereosinophilia syndrome with myocarditis has not been reported earlier following BBV152 vaccine administration.
Case Presentation: A young man without any co-morbidities presented with persistent periorbital swelling along with itchy swelling over fingers, resting tachycardia, and exertional breathlessness following the first dose of an inactivated SARS-CoV-2 vaccine (BBV152, COVAXIN).