Publications by authors named "G Karachaliou"
Currently, there is no reliable method of discerning between low-risk and high-risk intraductal papillary mucinous neoplasms (IPMNs). Operative resection is utilized in an effort to resect those lesions with high-grade dysplasia (HGD) prior to the development of invasive disease. The current guidelines recommend resection for IPMN that involve the main pancreatic duct.
View Article and Find Full Text PDFA significant number of patients with hepatocellular carcinoma (HCC) are usually diagnosed in advanced stages, that leads to inability to achieve cure. Palliative options are focusing on downstaging a locally advanced disease. It is well-supported in the literature that patients with HCC who undergo successful conversion therapy followed by curative-intent surgery may achieve a significant survival benefit compared to those who receive chemotherapy alone or those who are successfully downstaged with conversion therapy but not treated with surgery.
View Article and Find Full Text PDFArticle Synopsis
- NAFLD (non-alcoholic fatty liver disease) affects bile acid transporters in the liver, impacting their function and distribution across different zones in the liver.
- Using a machine learning approach, researchers analyzed liver biopsies to quantify the localization and abundance of key bile acid transporters in non-diseased, NAFL, and NASH (non-alcoholic steatohepatitis) samples.
- Findings revealed that NAFLD led to significant changes in the membrane localization of transporters, particularly BSEP and OATP1B3, which are linked to altered bile acid homeostasis and potentially contribute to disease progression.