Publications by authors named "G Kanellis"
Background: Cabazitaxel is an effective treatment in metastatic castration-resistant prostate cancer (mCRPC) patients previously exposed to docetaxel and novel hormonal treatments. Understanding the molecular biology of mCRPC disease and taking into account the several approved treatment options, biomarkers are needed to guide decision making including cabazitaxel treatment.
Methods: Cababone was a phase II translational study that attempted to identify predictors of cabazitaxel efficacy.
Article Synopsis
- Primary cutaneous lymphomas (PCLs) are a diverse group of skin-related non-Hodgkin lymphomas, primarily affecting T- or B-lymphocytes, and there's a lack of extensive data on their occurrence.
- A study in Attica, Greece, analyzed 1,189 patients diagnosed with PCL from 2009 to 2021, revealing a median diagnosis age of 62, with a higher prevalence in males, and an annual incidence rate (IR) of 2.2 per 100,000 individuals.
- The majority of cases were cutaneous T-cell lymphoma (CTCL) and specifically mycosis fungoides (MF), while the incidence rates increased until 2019 but
Purpose: Primary mediastinal large B-cell lymphoma (PMBCL) is a rare aggressive lymphoma predominantly affecting young female patients. Large-scale genomic investigations and genetic markers for risk stratification are lacking.
Patients And Methods: To elucidate the full spectrum of genomic alterations, samples from 340 patients with previously untreated PMBCL were investigated by whole-genome (n = 20), whole-exome (n = 78), and targeted (n = 308) sequencing.
Article Synopsis
- Scientists found that a gene called ZNF217 often has mutations in a type of cancer called primary mediastinal B cell lymphoma (PMBCL).
- In 33% of the patients studied, these mutations changed how certain genes worked, especially those related to inflammation and immune responses.
- When they removed ZNF217 in experiments, it messed up how cells were supposed to behave and develop, showing that ZNF217 helps control gene activity and cell growth in B cells.
Indolent systemic mastocytosis (ISM) represents the most common form of SM, typically following a slow clinical course. While anaphylactic reactions may come up in the life course of an ISM patient, these are often moderate and do not pose a threat to patient's health. Here, we present an undiagnosed case of ISM with recurrent severe anaphylactic episodes following consumption of food and emotional stress.
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