Physiologically based pharmacokinetic modelling of high- and low-dose etoposide: from adults to children.

Purpose: To evaluate the ability of a physiology-based pharmacokinetic (PBPK) model to predict the systemic drug exposure of high- and low-dose etoposide in children from a model developed with adult data.

Methods: Simulations were performed with PK-Sim(®) (Bayer Technology Services). Model development was done using data from adult patients receiving etoposide in a conventional and high-dose polychemotherapy regimen before stem cell transplantation.

[Sensitization to airborne ragweed pollen--a cause of allergic respiratory diseases in Germany?].

Background And Objective: Allergic skin and respiratory diseases show a high prevalence in most industrial countries. In addition, during the last years ragweed colonization has increased in Europe. Ambrosia pollen ( AMBROSIA ARTEMISIIFOLIA L.

Topoisomerase II beta expression level correlates with doxorubicin-induced apoptosis in peripheral blood cells.

Anthracyclines are widely used in oncology. Both the response and side-effects of anthracyclines are individually variable, but determinants or predictive markers of this variability are not available. We investigated the variability in the expression of the anthracycline targets topoisomerases II (topo II) alpha and beta and its significance for the apoptotic response following exposure to the anthracycline doxorubicin.

[Craniocerebral trauma and glioma].

There are only a few well documented cases in the literature which allow for the assumption of traumatic origin of some intracranial tumors. Four cases are presented in whom the authors have accepted the traumatic origin of gliomas because of it's evidence, but--from their scientific understanding of tumor development--without being convinced of such a correlation. It is stressed that scientific points of view and argumentation in social insurance affairs may differ and that they should be carefully distinguished.

[MR tomography following craniocerebral trauma: comparison with computed tomography, electroencephalography and neurologic status].

56 patients with head and brain trauma and in coma were studied prospectively by means of MRT, CT, EEG and neurological examination. All patients had initial CT and EEG admission. MRT showed that in our patients morphological return to normal was the exception.