[Clinical significance of intracellular cytokines in patients with yersiniosis].

Aim: To evaluate clinical value of intracellular content of interferon-gamma (If-g), IL-2 and IL-4 in different forms of yersiniosis.

Material And Methods: The number of If-g, IL-2 and IL-4 producing cells was estimated in 35 patients with generalized (n = 21, group 1) and secondary-focal (n = 14, group 2) forms of yersiniosis.

Results: The control over the number of If-g, IL-2 and IL-4 producing cells in the blood enables valid prognosis of the course and outcome of yersiniosis.

[Development of immunopathology in patients with yersinia infection].

Aim: To evaluate clinical significance of changes in IL-6 concentration and neopterin in peripheral blood of patients for prognosis of the course and outcome of yersinia infection (YI).

Material And Methods: Clinical examination and laboratory tests, 1-5-year follow-up were conducted in 68 patients with a cyclic, recurrent and lingering course of the disease. IL-6 and neopterin concentrations were measured in the course of the disease.

[Heart remodeling in patients with predialysis phase of chronic renal failure].

Aim: To investigate remodeling of the heart in patients with predialysis phase of chronic renal failure (CRF).

Material And Methods: Patients with predialysis phase of CRF (n = 61; serum creatinine 412.4 +/- 242.

[The effect of the blood serum factors of HIV-infected persons on the functional activity of the neutrophils in healthy donors].

The influence of 64 blood serum samples from HIV-infected patients at different stages of the infection on the functional activity of polymorphonuclear neutrophils (PMN) of 9 healthy donors was studied. In this study an increase in the production of oxygen radicals by PMN of the donors was revealed (in the chemiluminescence test), positive correlations between this increase and stages of HIV infection were followed. The presence of HIV-positive serum in the incubation medium led to the inhibition of phagocytosis and produced almost no changes in the capacity of PMN for its completion.