Practicality meets precision: Wearable vest with integrated multi-channel PCG sensors for effective coronary artery disease pre-screening.

The leading cause of mortality and morbidity worldwide is cardiovascular disease (CVD), with coronary artery disease (CAD) being the largest sub-category. Unfortunately, myocardial infarction or stroke can manifest as the first symptom of CAD, underscoring the crucial importance of early disease detection. Hence, there is a global need for a cost-effective, non-invasive, reliable, and easy-to-use system to pre-screen CAD.

Nipah virus outbreak trends in Bangladesh during the period 2001 to 2024: a brief review.

Nipah virus (NiV) is a zoonotic threat that has caused recurrent outbreaks in Bangladesh since 2001, raising significant public health concerns. This study provides a descriptive analysis of NiV outbreaks from 2001 to 2024, examining trends in infection and death rates and their correlation with climatic factors such as temperature, humidity, and rainfall. The findings highlight significant spikes in NiV cases during specific years, with environmental factors, particularly temperature and precipitation, showing solid correlations with outbreak patterns.

Luminescent Cd(II) Fumarate Bridging 1D Coordination Polymer: Ultra-Trace Level Detection of Cu in Aqueous Medium and Fabrication of Semiconducting Device.

In addressing the Sustainable Development Goals (SDGs) the UNDP has fixed 17 issues out of them clean water (SDG-6) and affordable energy (SDG-7) serve as decisive points towards sustenance of the society. Material chemistry plays a vital role to design new chemical compounds and exploring versatile activities towards the solution of pressing challenges. Copper, third abundant metal in human body following iron and zinc, is useful to monitor many metabolic processes.

Search for New Resonances Decaying to Pairs of Merged Diphotons in Proton-Proton Collisions at sqrt[s]=13 TeV.

A search is presented for an extended Higgs sector with two new particles, X and ϕ, in the process X→ϕϕ→(γγ)(γγ). Novel neural networks classify events with diphotons that are merged and determine the diphoton masses. The search uses LHC proton-proton collision data at sqrt[s]=13  TeV collected with the CMS detector, corresponding to an integrated luminosity of 138  fb^{-1}.

The key vulnerabilities and therapeutic opportunities in the USP7-p53/MDM2 axis in cancer.

The MDM2/MDMX-p53 circuitry is essential for controlling the development, apoptosis, immune response, angiogenesis, senescence, cell cycle progression, and proliferation of cancer cells. Research has demonstrated that USP7 exerts strong control over p53, MDM2, and MDMX stability, with multiple mediator proteins influencing the USP7-p53-MDM2/MDMX axis to modify p53 expression level and function. In cases where p53 is of the wild type (Wt-p53) in tumors, inhibiting USP7 promotes the degradation of MDM2/MDMX, leading to the activation of p53 signaling.