Corporate genome screening India (CoGsI) identified genetic variants association with T2D in young Indian professionals.

Rising cases of type 2 diabetes (T2D) in India, especially in metropolitan cities is an increasing concern. The individuals that were most affected are young professionals working in the corporate sector. However, the corporate sector has remained the least explored for T2D risk predisposition.

mRNA decay pre-complex assembly drives timely cell-state transitions during differentiation.

Complexes that control mRNA stability and translation promote timely cell-state transitions during differentiation by ensuring appropriate expression patterns of key developmental regulators. The Drosophila RNA-binding protein brain tumor (Brat) promotes the degradation of target transcripts during the maternal-to-zygotic transition in syncytial embryos and uncommitted intermediate neural progenitors (immature INPs). We identify ubiquitin-specific protease 5 (Usp5) as a candidate Brat interactor essential for the degradation of Brat target mRNAs.

Reduced-Graphene-Oxide-Based Thin Films: An Alternative Coating for Harsh Space Environments.

Polymeric materials are commonly used as the outermost layer in spacecraft passive thermal control. However, in geostationary earth orbit environments, the polymeric layer is susceptible to environmental hazards, particularly electrostatic charges. In this study, we develop a graphene-based coating on a polymeric polyimide (Kapton) and discuss its suitability in simulated harsh space environments for electrostatic dissipation.

Synthesis of fluorinated spiro-1,3-oxazines and thiazines Selectfluor-mediated intramolecular cyclization.

A fluorination-induced intramolecular cyclization for the synthesis of fluoro-substituted spiro-1,3-oxazine and spiro-1,3-thiazine derivatives is described. -(2-(Cyclohex-1-en-1-yl)ethyl)benzamide and benzothioamide are used as the substrates, and the cationic fluorinating agent Selectfluor works as the fluoride source. The reaction yields a single diastereomer.