Acute toxicity potential and impact on periodontal and periapical tissue of Pulp Out: A paste contained jatropha, sidaguri, and melittin.

Pulp Out, paste-contained jatropha sap, sidaguri roots, and melittin, has been studied to have potency used as an herbal-based devitalizing agent. Prior to clinical application, the toxicity of Pulp Out should be evaluated as it might leak from the cavity unintentionally and get into the digestive systems, which can cause either local or systemic effects. The present study aimed to evaluate the impact of Pulp Out application on periodontal and periapical tissue as well as acute toxicity in Wistar rats.