Publications by authors named "G K Petsas"
Study Question: Does follicular flushing increase the number of cumulus-oocyte complexes (COCs) retrieved compared to single aspiration?
Summary Answer: Follicular flushing significantly increases the number of COCs retrieved compared to single aspiration.
What Is Known Already: On the basis of published meta-analyses, follicular flushing does not seem to increase the number of oocytes retrieved, the probability of clinical pregnancy, or that of live birth and has been associated with an increase in the duration of oocyte retrieval. It should be noted, however, that all the eligible randomized controlled trials (RCTs) in these meta-analyses have randomized patients into either single aspiration or follicular flushing.
Study Question: What is the association between serum progesterone levels on the day of frozen embryo transfer (FET) and the probability of live birth in women undergoing different FET regimens?
Summary Answer: Overall, serum progesterone levels <7.8 ng/ml were associated with reduced odds of live birth, although the association between serum progesterone levels and the probability of live birth appeared to vary according to the route of progesterone administration.
What Is Known Already: Progesterone is essential for pregnancy success.
Article Synopsis
- This study investigates the link between serum progesterone levels and the success of frozen embryo transfers (FET) in women trying to conceive.
- By reviewing existing research, it finds that higher progesterone levels (below 10 ng/mL) significantly improve ongoing pregnancy rates and reduce miscarriage risks, particularly when using vaginal progesterone and blastocyst embryos.
- The authors suggest that a certain level of progesterone is crucial for embryo implantation, and they recommend more clinical trials to see if higher doses of progesterone can enhance FET outcomes for women with low levels.
Study Question: Can the grade of ascites, haematocrit (Ht), white blood cell (WBC) count and maximal ovarian diameter (MOD) measured on Day 3 be used to construct a decision-making algorithm for performing or cancelling embryo transfer in patients at high risk for severe ovarian hyperstimulation syndrome (OHSS) after an hCG trigger?
Summary Answer: Using cut-offs of ascites grade>2, Ht>39.2%, WBC>12 900/mm and MOD>85 mm on Day 3, a decision-making algorithm was constructed that could predict subsequent development of severe OHSS on Day 5 with an AUC of 0.93, a sensitivity of 88.