Publications by authors named "G K Nikolopoulos"
Gallbladder cancer (GBC) is a highly lethal and often overlooked malignancy increasingly affecting young adults. This study quantified the global proportion of GBC cases attributable to 10 key modifiable risk factors, employing Monte Carlo simulations and estimates from field-wide systematic review and meta-analysis. Approximately three-quarters of global GBC cases are attributable to key modifiable factors (74.
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- - The systematic review analyzed health-related quality of life (HRQoL) changes in breast cancer patients before and after surgical treatments: mastectomy (M), mastectomy with breast reconstruction (MBR), and breast-conserving surgery (BCS).
- - Six studies were included, revealing that by 24 months post-surgery, HRQoL improved or returned to pre-surgery levels for all groups, though MBR and BCS initially showed declines in physical HRQoL.
- - The findings highlight varying HRQoL challenges depending on surgery type and timing, suggesting the need for routine HRQoL assessments and psychological support during recovery.
Article Synopsis
- The study reviews the incidence and severity of community-acquired pneumonias (CAPs) in children at Archbishop Makarios Hospital from 2016 to 2023, focusing on changes during the pandemic years.
- During the first year of the COVID-19 pandemic, non-pharmacological interventions (NPIs) led to a drop in CAP admissions from an average of 32 per year to just 11.
- However, in the second year of the pandemic, admissions rose to 41, and the rate of complicated pneumonias nearly doubled, indicating a significant resurgence and worsening of pediatric CAPs post-restrictions.
Background: Enteric fever is a major public health challenge in developing countries. We conducted a systematic analysis from the Global Burden of Diseases 2021 Study to provide updated estimates of enteric fever's burden.
Methods: We presented estimates for incident cases and deaths, age-standardized incidence and mortality rates, years of life lost (YLLs), and case-fatality rates spanning the study period of 2017-2021, stratified by region, country, socio-demographic index (SDI), and age group.
Article Synopsis
- * After exposure to UV light, CS-B cells showed a delay in transcription progress and less dynamic chromatin compared to normal cells, revealing limitations in their response to DNA damage.
- * The research highlights that despite these impairments, transcription initiation still occurs in CS-B fibroblasts shortly after UV exposure, indicating a complex role for CSB beyond its known function in DNA repair.