[The nature of the lengthening of the G2 phase in the mitotic cycle of parenchymal cells of the mouse liver].

The phenomenon of G2 phase prolongation was found in the population of mouse hepatocytes. In normal postnatal liver growth, G2 phase prolongation in not pronounced and occurs in a small fraction of proliferating hepatocytes. In case of liver regeneration after removal of 2/3 of the organ, G2 phase prolongation is observed in a population of hepatocytes, which response to the proliferative stimulus first.

[Characteristic effects of rabbit liver extract on hepatocyte proliferation in the regenerating liver of mice of various ages].

Chalone isolated by the Verly method was injected into animals of different age (2 groups) under partial hepatectomy. The percentage of hepatocytes in S-, G2-, M- and post-M-periods was determined by morphoautoradiography. These parameters were used for the reconstruction of the extent and dynamics of cell proliferation during 36-48 hours of regeneration.

[Analysis of the prereplicative period of liver regeneration in young mice. The fate of the hepatocytes in the DNA synthesis phase at the moment of surgery].

In the liver of young mice after partial hepatectomy the hepatocytes which entered S-phase prior to the operation complete DNA synthesis in time and their major part is arrested in G2-phase. During the second half of lag-period (12-24 h after the operation) about half of these cells enters mitosis. Another half of the hepatocytes which were in S-phase during the operation does not proceed to mitosis.