[New approach to correction of ventricular septal defects complicated by critical pulmonary hypertension].

The authors have studied the effect of preoperative administration of Vazaprostan-20 into the pulmonary artery of patients with a defect of the interventricular septum (DIVS) and high pulmonary hypertension. By the end of the second day the patients examined had lower pressure in the pulmonary artery from 18% to 38%, higher intracardiac output in patients with the III A and III B degrees of pulmonary hypertension. In all the patients plasty of the DIVS was fulfilled under conditions of hypothermal extracorporeal circulation.

[Pharmacokinetics of the antineoplastic agent 14C-prospidin in rats according to distribution data of the radioactive label].

Prospidin--N,N3-di(beta-chloroethyl)-N1,N2-dispirotripiperazinium - is a broad-spectrum antineoplastic drug with low toxicity. Experiments on albino rats with transplanted sarcoma M-1 were made to study the distribution and kinetics of 14C-prospidin labeled in the dispirotripiperazinium part of the molecule. On being given intravenously the drug accumulated for 15 minutes.

[Pharmacokinetic characteristics of 14C-peritol based on data on its distribution in rat tissue].

Peritol (cyproheptadine) is chemically 1-methyl-4-(5-dibenzo-cyclohepta-trenilidin)-piperidine hydrochloride. It has a pronounced antihistamine and antiserotonin action. When injected intravenously to rats 14C-peritol is rapidly excreted from blood (T 1/2 = 2 h).