Comprehensive Analysis of Metabolic Changes in Mice Exposed to Corilagin Based on GC-MS Analysis.

Background: Corilagin is widely distributed in various medicinal plants. In recent years, numerous pharmacological activities of Corilagin have been reported, including anti-inflammatory, antiviral, hepatoprotective, anti-tumor, and anti-fibrosis effects. However, there is still a need for systematic metabolomics analysis to further elucidate its mechanisms of action.

Correlation between weight-adjusted waist index and coronary heart disease: NHANES 1999-2020.

Background: The weight adjusted waist index (WWI) represents a novel indicator for assessing central obesity. The objective of this study is to investigate the association between WWI and coronary heart disease (CHD).

Method: The data of 44,528 participants in total were gathered from NHANES database from 1999 to 2020.

Octa-Cationic Porphyrin-Functionalized Biocompatible Nanocomposite: A Promising Candidate for Enhanced Combinatorial Photodynamic and Photothermal Tumor Therapy.

The integration of photodynamic therapy (PDT) and photothermal therapy (PTT) offers a promising strategy for enhancing phototherapy efficiency. Herein, we present a dual-functional, biocompatible nanocomposite system for combination PDT/PTT therapy. The system utilizes a highly biocompatible nanoparticle assembled by an amphiphilic short peptide with the assistance of Zn as a carrier.

Knockout of Pro-Apoptotic BAX and BAK1 Genes in HEK293T Cells Enhances Adeno-Associated Virus (AAV) Production: AAV2 and AAV9.

Increasing demand for adeno-associated virus (AAV) used in gene therapy highlights the need to enhance AAV production. When intracellular AAV2 and extracellular AAV9 were produced in HEK293T cells using the triple transfection method, apoptosis occurred during the AAV production. To mitigate apoptosis induced by AAV production, the pro-apoptotic BAX/BAK1 genes were knocked out in HEK293T cells.

Natural Enemies Acquire More Prey Aphids from Hormone-Treated Insect-Attracting Plants.

Exogenous plant hormones regulate the agronomic and physiological performance of plants and thus can influence the abundance of insect groups. We surveyed the arthropods on flowering plants and found that the abundance of natural enemies and in the plots treated with salicylic acid (SA) and indole acetic acid (IAA) was significantly increased compared with those in the clean water (control) plots. Then, we investigated the effects of spraying SA, IAA, and clean water on the population parameters of reared on Our results from the age-stage, two-sex life table analysis revealed a significantly shorter pre-adult duration for aphids reared on SA-treated compared to those reared on the other two treatments.