Possible effect of variable membrane potential of a cancer cell on different carcinogenic processes.

Cancer cells (unlike normal analogs) have a variable membrane potential on their surface, which depends on the intensity of metabolism of this type of cells and the environmental hydrogen index: in the case of low-pH (acid medium) they are known to have either a low negative or even positive charge, while in the case of high-pH (alkaline medium) - a relatively high negative charge. In this paper we suggest that the processes of metastasis, progression and invasion ongoing in a macro organism can be ascribed to the presence of exactly this variable electric charge in a cancer cell.

Tumor cell formation by normal somatic cells fusing and cancer prevention prospects.

Malignant transformation might be ascribed to one of the rather widespread processes taking place in the organism daily and being genetically inherited in a normal somatic cell. In order that normal cells are transformed into malignant ones, they should undergo the following two stages: (1) initiation - the precancerous cell (first-stage synkarion) formation, and (2) promotion - the true tumor cell (second-stage synkaryon) formation. For promoting the tumor process, i.

A paradoxical idea of cancer's resolution.

Polykaryocytes arising by means of fusion represent genetic deadlock. They cannot enter the S-phase of mitosis and they die quickly. A concept of cancer treatment proposes the conversion of tumor cells synchronously into the stage of unviable polykaryocytes, which leads to dissociation of the tumor substrate, reduction of the mass of tumor, and even to its resolution.

Hypothesis explaining simultaneous development of acquired immunodeficiency syndrome and malignant tumors.

A possible mechanism for explanation of the simultaneous development of acquired immunodeficiency syndrome (AIDS) and malignant tumors may be based on the cell-fusion process with the participation of immunocompetent cells. If the fusion proceeds with a high intensity, i.e.