Pan-inhibition of super-enhancer-driven oncogenic transcription by next-generation synthetic ecteinascidins yields potent anti-cancer activity.

The plasticity of cancer cells facilitates their ability to adopt heterogeneous differentiation states, posing a significant challenge to therapeutic interventions. Specific gene expression programs, driven in part by super-enhancers (SEs), underlie cancer cell states. Here we successfully inhibit SE-driven transcription in phenotypically distinct metastatic melanoma cells using next-generation synthetic ecteinascidins.

Pharmacy Integrated Transitions (PIT) trial: a protocol for a pragmatic cluster-randomised crossover trial.

Introduction: Ineffective coordination during care transitions from hospitals to skilled nursing facilities (SNFs) costs Medicare US$2.8-US$3.4 billion annually and results in avoidable adverse events.

Vaginal drainage of semen in underwear: A forensic study.

The UK and Ireland Association of Forensic Science Providers' (AFSP) Body Fluid Forum (BFF) conducted this research to investigate the occurrence of seminal fluid draining from the vagina onto underwear worn after penile-vaginal sexual intercourse with internal ejaculation. This study shows the differing effects of the female being either supine or upright and active on possible patterns of seminal staining on underwear, and the effect of time since intercourse on the deposition of seminal fluid on underwear in a limited study. Here, we demonstrate that post vaginal intercourse different distributions of semen staining can be observed on underwear.

Exploring past research to move forward: a scoping review of aims, outcomes, and recommendations in parental mental illness qualitative research.

Introduction: As parental mental illness is a global public health concern, rigorous qualitative research is central to understanding families' experiences, needs and outcomes to inform optimal service provision in adult mental health and children's social services.

Methods: The current review identified, appraised and synthesized international qualitative research exploring Families and Parent Mental Illness (FaPMI) research to determine the focus, findings and outcomes and to summarize the recommendations made about the direction of future research. Findings are classified according to outcomes for children, parents, and families.

The transfer of spermatozoa onto children's underwear during normal domestic laundering activities.

In cases of sexual assaults involving children, biological evidence such as semen is often found on clothes rather than on intimate swabs. Two cases involving young girls were submitted to one of the AFSP BFF forensic science laboratories instigating further research into the background levels of semen on children's underwear after being laundered, without sexual acts occurring. This study considered the potential for background levels of semen in the washing machine and the levels of semen transferred with varying laundry storage and washing arrangements.