The translational potential of epigenetic modulatory bioactive phytochemicals as adjuvant therapy against cancer.

In preclinical studies, bioactive phytochemicals have shown enormous potential therapeutic efficacy against various human malignancies. These natural compounds have been shown to possess an inherent potential to alter the molecular signaling pathways and epigenetic modulatory activity involved in multiple physiological functions. Recently, epigenetic therapy has emerged as an important therapeutic modality due to the reversible nature of epigenetic alterations.

Computational and experimental insights into pharmacological potential: Synthesis, in vitro evaluation, and molecular docking analysis of bioactive urea and thiourea derivatives.

This study delves into the synthesis, in vitro assessment, and molecular docking analysis of bioactive urea and thiourea derivatives, which have garnered significant attention in pharmaceutical chemistry due to their versatile chemical reactivity and potential therapeutic applications One pot synthetic approach was utilized to develop a diverse class of these compounds. Subsequent biological assessments, including antimicrobial assays, demonstrated their pharmacological potential by inhibiting pathogenic microorganisms. Molecular docking analysis offered computational insights into the interactions between these compounds and specific biomolecules, shedding light on their potential mechanisms of action.

Silicon mediated heavy metal stress amelioration in fruit crops.

Fruit crops are essential for human nutrition and health, yet high level of heavy metal levels in soils can degrade fruit quality. These metals accumulate in plant roots and tissues due to factors like excessive fertilizer and pesticide use, poor waste management, and unscientific agricultural practices. Such accumulation can adversely affect plant growth, physiology, and yield.

Advanced Optimization of Surface Characteristics and Material Removal Rate for Biocompatible Ti6Al4V Using WEDM Process with BBD and NSGA II.

Machining titanium alloy (Ti6Al4V) used in orthopedic implants via conventional metal cutting processes is challenging due to excessive cutting forces, low surface integrity, and tool wear. To overcome these difficulties and ensure high-quality products, various industries employ wire electrical discharge machining (WEDM) for precise machining of intricate shapes in titanium alloy. The objective is to make WEDM machining parameters as efficient as possible for machining the biocompatible alloy Ti6Al4Vusing Box-Behnken design (BBD) and nondominated sorting genetic algorithm II (NSGA II).

Metal-based nanomaterials and nanocomposites as promising frontier in cancer chemotherapy.

Cancer is a disease associated with complex pathology and one of the most prevalent and leading reasons for mortality in the world. Current chemotherapy has challenges with cytotoxicity, selectivity, multidrug resistance, and the formation of stemlike cells. Nanomaterials (NMs) have unique properties that make them useful for various diagnostic and therapeutic purposes in cancer research.