A validation experiment: Utilizing ultraviolet light to disinfect high use nursing equipment.

Background: Healthcare staff utilize equipment that can travel from patient room to patient room. Additionally, nursing and environmental services staff may not always communicate clearly regarding cleaning. The purpose of this study was to identify if a portable UV-C tent utilized with a UV-C device (Xenex® LightStrike™ Robot) can effectively disinfect high use equipment.

Inverse design for waveguide dispersion with a differentiable mode solver.

Inverse design of optical components based on adjoint sensitivity analysis has the potential to address the most challenging photonic engineering problems. However, existing inverse design tools based on finite-difference-time-domain (FDTD) models are poorly suited for optimizing waveguide modes for adiabatic transformation or perturbative coupling, which lies at the heart of many important photonic devices. Among these, dispersion engineering of optical waveguides is especially challenging in ultrafast and nonlinear optical applications involving broad optical bandwidths and frequency-dependent anisotropic dielectric material response.

Creeping Fat-Derived Free Fatty Acids Induce Hyperplasia of Intestinal Muscularis Propria Muscle Cells: A Novel Link Between Fat and Intestinal Stricture Formation in Crohn's Disease.

Background & Aims: In Crohn's disease, wrapping of mesenteric fat around the bowel wall, so-called "creeping fat," is highly associated with strictures. The strongest contributor to luminal narrowing in strictures is a thickening of the human intestinal muscularis propria (MP). We investigated creeping fat-derived factors and their effect on mechanisms of human intestinal MP smooth muscle cell (HIMC) hyperplasia.

Topological-charge-tunable and wavelength- switchable vortex laser enabled by a helically twisted high-absorption few-mode erbium-doped fiber.

Vortex beams carrying orbital angular momentum (OAM) offer a solution for enhancing spatial degrees of freedom, particularly in conjunction with wavelength division multiplexing, which can significantly boost data capacity for optical communication. Addressing the increasing demand for high information-carrying capacity, we present a dynamically tunable OAM laser source in this study. We demonstrate a ring-cavity vortex fiber laser employing intra-cavity mode conversion through a helically twisted high-absorption few-mode erbium-doped fiber (HA-FM-EDF).

Hyperglycemic environments directly compromise intestinal epithelial barrier function in an organoid model and hyaluronan (∼35 kDa) protects via a layilin dependent mechanism.

Background: Metabolic syndrome and diabetes in obese individuals are strong risk factors for development of inflammatory bowel disease (IBD) and colorectal cancer. The pathogenic mechanisms of low-grade metabolic inflammation, including chronic hyperglycemic stress, in disrupting gut homeostasis are poorly understood. In this study, we sought to understand the impact of a hyperglycemic environment on intestinal barrier integrity and the protective effects of small molecular weight (35 kDa) hyaluronan on epithelial barrier function.