Integrative determination of atomic structure of mutant huntingtin exon 1 fibrils implicated in Huntington disease.

Neurodegeneration in Huntington's disease (HD) is accompanied by the aggregation of fragments of the mutant huntingtin protein, a biomarker of disease progression. A particular pathogenic role has been attributed to the aggregation-prone huntingtin exon 1 (HTTex1), generated by aberrant splicing or proteolysis, and containing the expanded polyglutamine (polyQ) segment. Unlike amyloid fibrils from Parkinson's and Alzheimer's diseases, the atomic-level structure of HTTex1 fibrils has remained unknown, limiting diagnostic and treatment efforts.

Factors affecting hormonal outcomes in patients undergoing surgery for non-functioning pituitary neuroendocrine tumors: a prospective observational study.

Surgical resection of non-functioning pituitary neuroendocrine tumors (NF-PitNET) is associated with new onset hormonal axis (HA) dysfunction, and factors predicting HA dysfunction are controversial, especially in large and giant NF-PitNET. Thus, we evaluated the postoperative hormonal function and assessed factors affecting HA dysfunction in patients with NF-PitNET. This prospective observational study involved 50 patients who underwent endoscopic surgical resection of NF-PitNET in the Department of Neurosurgery (April 2023-March 2024).

Blockchain's Transformative Potential in Healthcare.

Blockchain's transformative potential, its current applications, and the path forward for its integration into the healthcare ecosystem are all explored in the journal Blockchain in Healthcare Today. The healthcare industry is facing significant challenges and opportunities after COVID-19. As we navigate the complexities of increasing healthcare costs and technological updates for better patient outcomes, innovative technologies are emerging as pivotal tools for healthcare transformation.

Scientific Advances in Cancer Detection Using Raman Spectroscopy.

Aim: The present study is focused to investigate the role of Raman spectroscopy (RM) for cancer detection.

Methods: In this review, we explored a number of scientific databases including PubMed, Web of Science, Embase and Google Scholar for research studies on Raman spectroscopy for diagnosing cancer. We reported key outcomes of research studies conducted involving Raman spectroscopy for diagnosis of cancer and highlighting the potential of novel Raman spectroscopy for diagnosing cancer in our review.

Torrential intraoral bleed in a mandibular arteriovenous malformation: Resuscitation under nonoperating room settings.

Arteriovenous malformation (AVM) of the head and neck, though rare, can present significant clinical challenges, particularly during dental procedures. This case report details the acute management of a 7-year-old girl with an AVM in the right mandible, with sudden, severe, torrential intraoral hemorrhage during an angioembolization procedure, necessitating immediate airway management and hemodynamic stabilization in a nonoperating room anesthesia (NORA) setting. Persistent bleeding led to a multidisciplinary intervention, including external carotid artery ligation and right hemimandibulectomy, achieving hemostasis.