Randomized prospective controlled trial of recombinant granulocyte colony-stimulating factor as adjunctive therapy for limb-threatening diabetic foot infection.

Adult diabetic patients admitted to our Diabetes Center from September 1996 to January 1998 for severe, limb-threatening foot infection were consecutively enrolled in a prospective, randomized, controlled clinical study aimed at assessing the safety and efficacy of recombinant human granulocyte colony-stimulating factor (G-CSF) (lenograstim) as an adjunctive therapy for the standard treatment of diabetic foot infection. Forty patients, all of whom displayed evidence of osteomyelitis and long-standing ulcer infection, were randomized 1:1 to receive either conventional treatment (i.e.

An overview of upper extremity cumulative trauma disorders in pianists.

Many instrumentalists suffer from overuse syndrome due to repetitive and sustained motions required of the upper extremity. Overuse injuries in pianists are frequently caused by lack of rest breaks, deconditioned upper extremities, performance technique, and anatomical limitations of the hand and fingers. This article examines the precipitating factors of overuse syndrome through a case study approach.