Strategies for Improving Contact-Electro-Catalytic Efficiency: A Review.

Contact-electro-catalysis (CEC) has emerged as a promising catalytic methodology, integrating principles from solid-liquid triboelectric nanogenerators (SL-TENGs) into catalysis. Unlike conventional approaches, CEC harnesses various forms of mechanical energy, including wind and water, along with other renewable sources, enabling reactions under natural conditions without reliance on specific energy inputs like light or electricity. This review presents the basic principles of CEC and discusses its applications, including the degradation of organic molecules, synthesis of chemical substances, and reduction of metals.

Identification of regulator gene and pathway in myocardial ischemia-reperfusion injury: a bioinformatics and biological validation study.

Background: Acute myocardial infarction (AMI) is the primary cause of cardiac mortality worldwide. However, myocardial ischemia-reperfusion injury (MIRI) following reperfusion therapy is common in AMI, causing myocardial damage and affecting the patient's prognosis. Presently, there are no effective treatments available for MIRI.

Lipid-siRNA Organization Modulates the Intracellular Dynamics of Lipid Nanoparticles.

Lipid nanoparticles (LNPs) are widely used for delivering therapeutic nucleic acids, yet the relationship between their internal structure and intracellular behavior, particularly before RNA release, remains unclear. Here, we elucidate how lipid-siRNA organization within LNPs can modulate their intracellular delivery dynamics. We use cryo-electron microscopy and photochemical assays to reveal that increased siRNA loading can reduce helper lipids' distribution to the LNP surface, while siRNA consistently localizes near the surface.

The effects of training intervention on the prevention of knee joint injuries: a systematic review and meta-analysis.

Objective: To evaluate the impact of neuromuscular, core strength, balance, and proprioceptive training on preventing knee injuries in young athletes, to identify optimal intervention characteristics.

Methods: This review followed the 2020 guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). A systematic search of English and Chinese literature in databases included PubMed, Web of Science, EBSCO, CNKI, and Wanfang, covering studies published from January 1, 2000, to 12 April 2024.

Apigenin ameliorates inflamed ulcerative colitis by regulating mast cell degranulation via the PAMP-MRGPRX2 feedback loop.

Purpose: The aim of this study was to investigate the therapeutic effect of API on UC via the regulation of PAMP-MRGPRX2-mediated mast cells (MCs) degranulation.

Background: The pro-inflammatory positive feedback loop mediated by Mas-related G-protein-coupled receptor X2 (MRGPRX2) and its endogenous ligand, PAMP-12, is associated with ulcerative colitis (UC) progression. However, the therapeutic strategies that target MRGPRX2 in the treatment of UC are less reported.