Publications by authors named "G J Wise"
Article Synopsis
- The FDA imposed a "black box" warning on fluoroquinolones starting in 2008 due to safety concerns, impacting their use in treating UTIs in hospitals from 2000 to 2020.
- A study analyzed nearly 10 million UTI patient encounters, finding that fluoroquinolone usage dropped significantly from 61.7% to 11.7%, while ceftriaxone usage rose from 26.4% to 63.6%.
- The research revealed a 28.9% decline in fluoroquinolone resistance and indicated that the FDA warnings influenced antibiotic prescribing patterns in a way that changed resistance profiles.
Population-based studies to identify disease-associated risk alleles typically require samples from a large number of individuals. Here, we report a human-induced pluripotent stem cell (hiPSC)-based screening strategy to link human genetics with viral infectivity. A genome-wide association study (GWAS) identified a cluster of single-nucleotide polymorphisms (SNPs) in a cis-regulatory region of the NDUFA4 gene, which was associated with susceptibility to Zika virus (ZIKV) infection.
View Article and Find Full Text PDFContact chemoreception in multi-modal sensing of prey by Octopus.
J Comp Physiol A Neuroethol Sens Neural Behav Physiol
May 2022
Octopuses have keen vision and are generally considered visual predators, yet octopuses predominantly forage blindly in nature, inserting their arms into crevices to search and detect hidden prey. The extent to which octopuses discriminate prey using chemo- versus mechano-tactile sensing is unknown. We developed a whole-animal behavioral assay that takes advantage of octopuses' natural searching behavior to test their ability to discriminate prey from non-prey tastes solely via contact chemoreception.
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