Plasma n-3 polyunsaturated fatty acid levels and colorectal cancer risk in the UK Biobank: Evidence of non-linearity, as well as tumour site- and sex-specificity.

Background: The relationship between n-3 polyunsaturated fatty acid (PUFA) intake and colorectal cancer (CRC) risk is unclear. Blood n-3 PUFA concentration is a biomarker of dietary n-3 PUFA intake. We examined the relationship between plasma n-3 PUFA concentrations and CRC risk in UK Biobank (UKBB) participants.

Fish oil supplement use modifies the relationship between dietary oily fish intake and plasma -3 PUFA levels: an analysis of the UK Biobank.

Observational evidence linking dietary -3 PUFA intake and health outcomes is limited by a lack of robust validation of dietary intake using blood -3 PUFA levels and potential confounding by fish oil supplement (FOS) use. We investigated the relationship between oily fish intake, FOS use and plasma -3 PUFA levels in 121 650 UK Biobank (UKBB) participants. Ordinal logistic regression models, adjusted for clinical and lifestyle factors, were used to quantify the contribution of dietary oily fish intake and FOS use to plasma -3 PUFA levels (measured by NMR spectroscopy).

Randomised, placebo-controlled, phase 3 trial of the effect of the omega-3 polyunsaturated fatty acid eicosapentaenoic acid (EPA) on colorectal cancer recurrence and survival after surgery for resectable liver metastases: EPA for Metastasis Trial 2 (EMT2) study protocol.

Introduction: There remains an unmet need for safe and cost-effective adjunctive treatment of advanced colorectal cancer (CRC). The omega-3 polyunsaturated fatty acid eicosapentaenoic acid (EPA) is safe, well-tolerated and has anti-inflammatory as well as antineoplastic properties. A phase 2 randomised trial of preoperative EPA free fatty acid 2 g daily in patients undergoing surgery for CRC liver metastasis showed no difference in the primary endpoint (histological tumour proliferation index) compared with placebo.

Ursodeoxycholic acid in the management of symptomatic gallstone disease: systematic review and clinician survey.

Background: Symptomatic gallstones are common. Ursodeoxycholic acid (UDCA) is a bile acid that dissolves gallstones. There is increasing interest in UDCA for symptomatic gallstones, particularly in those unfit for surgery.

Does ALT Correlate with Survival After Liver Resection for Colorectal Liver Metastases?

Background: The pringle manoeuvre is commonly used during hepatectomy, which may cause ischaemia-reperfusion injury and transient liver dysfunction. Post-operative liver transaminases are often used to assess ischaemia-reperfusion injury, although there is conflicting evidence on survival outcomes. The primary aim was to assess post-operative alanine aminotransferase (ALT) with survival outcomes.