Sustainable application of waste gangue mortar in coal mine tunnel support.

With the increase in coal mining depths, soft and fractured roadway surrounding rocks require grouting and a sprayed protective layer for maintenance. Simultaneously, extensive accumulation of coal gangue causes diverse environmental issues. To enhance on-site coal gangue utilization, this study replaced river sand and cement with coal gangue to develop a novel cement-based mortar for supporting coal mine roadways.

WGAN-based multi-structure segmentation of vertebral cross-section MRI using ResU-Net and clustered transformer.

The vertebral foramen, lamina, and vertebral body are three critical components of the spine structure, essential for maintaining spinal connectivity and stability. Accurately segmenting lumbar structures such as the vertebral body, vertebral foramen, and lamina in MRI cross-sections helps doctors better understand and diagnose the pathological causes of spine-related diseases. This study presents a multi-structure semantic segmentation method for vertebral transverse section MRI slices using WGAN with a residual U-Net and clustered Transformer.

Photoresponsive prodrug-based liposomes for controllable release of the anticancer drug chlorambucil.

The on-demand delivery and release of chemotherapeutic drugs have attracted great attention, among which photoresponsive prodrug systems have shown specific advantages for effective cancer treatment due to their spatiotemporal control, non-invasive nature and easy operation. Unlike the traditional strategy of physical encapsulation of drugs in liposomes, we herein report a biomimetic and photoresponsive drug delivery system (DDS) based on a lipid prodrug liposomal formulation (LNC), which combines the features of the prodrug and nanomedicines, and can realize photocontrollable release of anticancer drugs. The lipid prodrug comprises three functional moieties: a single-arm phospholipid (Lyso PC), an -nitrobenzyl alcohol (NB) and chlorambucil (CBL).

Assessment of the importance and catalytic role of chromium oxide and chromium carbide for hydrogen generation hydrolysis of magnesium.

Increasing energy demands and low-carbon emission energy carriers are global challenges for renewable energy resources. Regarding the aforementioned issues, magnesium-based composites are promising candidates for energy carriers. However, rapid initial hydrolysis kinetics and higher hydrogen yields are the objectives for practical applications.

The extracellular matrix with a continuous gradient of SDF1guides the oriented migration of human umbilical cord mesenchymal stem cells.

The extracellular matrix (ECM) plays a crucial role in maintaining cell morphology and facilitating intercellular signal transmission within the human body. ECM has been extensively utilized for tissue injury repair. However, the consideration of factor gradients during ECM preparation has been limited.