Publications by authors named "G J Scheffer"
Background: Malignant hyperthermia (MH) susceptibility is associated with variants in RYR1, the gene encoding the skeletal muscle ryanodine receptor-1 (RyR1), in 70-75% of patients. Functional characterisation demonstrating an increased sensitivity to RyR1 agonists is necessary among other criteria for inclusion in the European Malignant Hyperthermia Group list of MH susceptibility diagnostic variants.
Methods: Seven variants in the RYR1 gene, p.
Article Synopsis
- Colorectal surgery often leads to significant postoperative complications, mainly infections, potentially due to monocyte epigenetic changes and immune tolerance.
- A study involving 100 patients measured changes in damage-associated molecular patterns (DAMPs) and cytokine production, alongside exploratory analyses of proteins and DNA accessibility in monocytes.
- Results showed significant increases in plasma DAMPs, particularly HMGB1 and mitochondrial DNA post-surgery, while in vitro tests revealed that HSP70 and HMGB1 reduced the cytokine production capacity of immune cells.
Background: Concerns regarding residual neuromuscular block (RNMB) have persisted since the introduction of neuromuscular blocking agents, with reported incidences in the 21st century up to 50%. Advances in neuromuscular transmission (NMT) monitoring and the introduction of sugammadex have addressed this issue, but the impact of these developments remains unclear.
Methods: This prospective observational study evaluated RNMB in 500 surgical patients in a large Dutch teaching hospital with readily available quantitative NMT monitoring and reversal agents.
Article Synopsis
- The study looked at how safe it is for Physician Assistants to give sedation to kids during painful medical procedures like bone marrow tests.
- They checked if any kids had problems like low oxygen levels or needed extra help breathing during the process.
- The results showed that there were no serious issues and only a few minor problems, which suggests that it can be done safely by trained Physician Assistants.
Background: Increasing evidence supports a positive relationship between the intensity of early postoperative pain, and the risk of 30-day postoperative complications. Higher pain levels may hamper recovery and contribute to immunosuppression after surgery. This leaves patients at risk of postoperative complications.
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